{"id":"W2981224782","doi":"10.1016/j.jalz.2019.06.4250","title":"IC‐P‐136: SYNTHESIS AND <i>IN VIVO</i> BRAIN PET EVALUATION OF 1‐METHYL‐4‐PIPERIDYL <i>P‐</i><sup>18</sup>[F]FLOUROBENZOATE (TRV6501): A BUTYRYLCHOLINESTERASE‐SPECIFIC RADIOLIGAND FOR ALZHEIMER'S DISEASE","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Saint Vincent University; Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"Butyrylcholinesterase; Radioligand; In vivo; Positron emission tomography; Temporal cortex; Neuroscience; Alzheimer's disease; Chemistry; Pathology; Medicine; Internal medicine; Psychology; Acetylcholinesterase; Disease; Aché; Biochemistry; Biology; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002502896,0.0006940319,0.0003466713,0.0002269945,0.0001502434,0.0002625188,0.0006247394,0.0005528168,0.001457507],"category_scores_gemma":[0.0002022528,0.0002485192,0.0001966838,0.0002857996,0.0003013636,0.0003005413,0.0001459324,0.0006322369,0.0007778424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005716262,"about_ca_system_score_gemma":0.0007733496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003292621,"about_ca_topic_score_gemma":0.002325093,"domain_scores_codex":[0.9998494,0.00002541002,0.00001203366,0.00003773292,0.00003535113,0.00003990567],"domain_scores_gemma":[0.9998562,0.00001398836,0.00003238197,0.00002103122,0.0000290067,0.00004734996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003170412,0.00006839111,0.00007820841,0.0001095879,0.000009177381,0.00007292767,0.00001576711,0.0003518137,0.9958341,0.0001011778,0.0001718818,0.002869802],"study_design_scores_gemma":[0.00005306622,0.00100099,0.0005971448,0.000006939557,0.00002636327,0.000403447,0.000005768153,0.0005901743,0.9936321,0.00001708492,0.003655301,0.00001155139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465753,0.006278796,0.03115711,0.0003464378,0.00008254899,0.0008147592,0.003463499,0.0006895099,0.01059201],"genre_scores_gemma":[0.9326225,0.005200651,0.04513917,0.0002627108,0.00003310906,0.0004872133,0.005618407,0.0001749818,0.01046132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003292621,"threshold_uncertainty_score":0.006546915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04749308993258549,"score_gpt":0.3107947579211707,"score_spread":0.2633016679885852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}