{"id":"W2981226218","doi":"10.1093/sleep/zsz252","title":"Evaluation of the abuse potential of pitolisant, a selective H3-receptor antagonist/inverse agonist, for the treatment of adult patients with narcolepsy with or without cataplexy","year":2019,"lang":"en","type":"article","venue":"SLEEP","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Bioprojet; Harmony Biosciences","keywords":"Phentermine; Placebo; Narcolepsy; Medicine; Crossover study; Anesthesia; Inverse agonist; Cataplexy; Pharmacology; Agonist; Internal medicine; Modafinil; Weight loss; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001383824,0.0004471517,0.0007791481,0.0001463302,0.000164786,0.0002067853,0.0002415721,0.0003262874,0.001751902],"category_scores_gemma":[0.001502992,0.0001662961,0.0005146749,0.0001635857,0.0003582233,0.0003637859,0.000143587,0.0005073722,0.000207372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003646413,"about_ca_system_score_gemma":0.0004251131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003365411,"about_ca_topic_score_gemma":0.001293964,"domain_scores_codex":[0.9994674,0.0003302741,0.00005349406,0.00004583878,0.00007319996,0.00002977818],"domain_scores_gemma":[0.9990208,0.0003453578,0.00033822,0.00005582597,0.00008345474,0.0001562686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5215309,0.0194343,0.09172229,0.001897324,0.002885906,0.0010808,0.0006607285,0.001478899,0.1711939,0.0002127053,0.0007044428,0.1871978],"study_design_scores_gemma":[0.04342037,0.7821051,0.1547913,0.00005403979,0.001291262,0.001778323,0.000188989,0.001265813,0.01295768,0.00004729153,0.002070697,0.00002903671],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982768,0.0011592,0.0001232827,0.00003442298,0.000008605021,0.0001074157,0.00007570264,0.0000043747,0.0002101476],"genre_scores_gemma":[0.9980592,0.0009257403,0.0005173748,0.00006026001,0.00003096895,0.00009046367,0.0001345527,0.000002075368,0.0001794583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001751902,"threshold_uncertainty_score":0.007318437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02723128919079575,"score_gpt":0.2921740499948066,"score_spread":0.2649427608040109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}