{"id":"W2981226218","doi":"10.1093/sleep/zsz252","title":"Evaluation of the abuse potential of pitolisant, a selective H3-receptor antagonist/inverse agonist, for the treatment of adult patients with narcolepsy with or without cataplexy","year":2019,"lang":"en","type":"article","venue":"SLEEP","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Bioprojet; Harmony Biosciences","keywords":"Phentermine; Placebo; Narcolepsy; Medicine; Crossover study; Anesthesia; Inverse agonist; Cataplexy; Pharmacology; Agonist; Internal medicine; Modafinil; Weight loss; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002477535,0.0001871264,0.0002969732,0.0000743645,0.0001728822,0.00001938479,0.0003791181,0.00005101659,0.0000898528],"category_scores_gemma":[0.000158869,0.00008055261,0.0001057914,0.0004851979,0.000441889,0.0001207464,0.00002969598,0.00007814808,0.000005389699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001443006,"about_ca_system_score_gemma":0.0003870589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004451729,"about_ca_topic_score_gemma":0.0005074216,"domain_scores_codex":[0.9973635,0.0002831911,0.0002681056,0.0003614382,0.001441132,0.0002826261],"domain_scores_gemma":[0.99765,0.0002181349,0.0003568018,0.0005657853,0.001160253,0.00004900579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05708674,0.0128046,0.6091613,0.0005537413,0.001659654,0.000003463261,0.03334963,0.009749842,0.1907309,0.0006344573,0.0004600765,0.08380561],"study_design_scores_gemma":[0.01596361,0.006979057,0.02484892,0.00010354,0.0007870577,0.000003111433,0.001258652,0.02726629,0.9221889,0.00003480635,0.0003388166,0.000227194],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953254,0.0000207412,0.0001495035,0.0000586252,0.0002115657,0.003759753,0.00032793,0.000008762375,0.0001377083],"genre_scores_gemma":[0.9993088,0.00002439435,0.00009423836,0.00002641518,0.00003395603,0.0003080519,0.0000139311,0.00002728085,0.0001629207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.731458,"threshold_uncertainty_score":0.328484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02723128919079575,"score_gpt":0.2921740499948066,"score_spread":0.2649427608040109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}