{"id":"W2981261950","doi":"10.1182/bloodadvances.2018026575","title":"Generation and function of progenitor T cells from StemRegenin-1–expanded CD34+ human hematopoietic progenitor cells","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada First Research Excellence Fund; National Cancer Institute; National Institutes of Health; Children's Cancer Research Fund; Ontario Institute for Regenerative Medicine; Krembil Foundation; University of Toronto","keywords":"Progenitor cell; CD34; Haematopoiesis; Progenitor; Cell biology; Function (biology); Interleukin 3; Stem cell; Biology; Immunology; T cell; Antigen-presenting cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878977,0.0003006482,0.0001825122,0.0002055273,0.0001338635,0.0002817581,0.0001429823,0.0001950243,0.001281965],"category_scores_gemma":[0.00009549092,0.00009555012,0.0001887269,0.0001307747,0.0001189956,0.0001178955,0.000162247,0.0004645858,0.0004731238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009957267,"about_ca_system_score_gemma":0.0001402694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003198903,"about_ca_topic_score_gemma":0.0003169085,"domain_scores_codex":[0.9998993,0.0000209129,0.0000128952,0.0000210155,0.00002600507,0.00001997576],"domain_scores_gemma":[0.9999552,0.000006837852,0.000007798177,0.000009324787,0.000006075184,0.00001487317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002348241,0.00008392449,0.0004434978,0.00004487397,0.000005545898,0.0000658621,0.0000406739,0.0001765599,0.9922534,0.0001489901,0.00005794693,0.006443963],"study_design_scores_gemma":[0.00005970217,0.00159457,0.007058704,0.00001161578,0.00003406282,0.0006038896,0.00002762553,0.001531707,0.9858229,0.00007694087,0.003173387,0.000004967777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921098,0.001415201,0.004272296,0.00003682464,0.00001153852,0.0001357869,0.0004088579,0.00004781692,0.001561757],"genre_scores_gemma":[0.9925627,0.0008499295,0.003476321,0.0000340754,0.00001314269,0.000100348,0.001166341,0.00001623218,0.001781013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281965,"threshold_uncertainty_score":0.004288614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414054077781971,"score_gpt":0.2921499308567681,"score_spread":0.2680093900789484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}