{"id":"W2981261950","doi":"10.1182/bloodadvances.2018026575","title":"Generation and function of progenitor T cells from StemRegenin-1–expanded CD34+ human hematopoietic progenitor cells","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada First Research Excellence Fund; National Cancer Institute; National Institutes of Health; Children's Cancer Research Fund; Ontario Institute for Regenerative Medicine; Krembil Foundation; University of Toronto","keywords":"Progenitor cell; CD34; Haematopoiesis; Progenitor; Cell biology; Function (biology); Interleukin 3; Stem cell; Biology; Immunology; T cell; Antigen-presenting cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00017207,0.000215878,0.0004363446,0.0001162235,0.00008009763,0.00003541175,0.0001002243,0.0001217554,0.0009819384],"category_scores_gemma":[0.000009554458,0.0001860948,0.0001068955,0.0001728823,0.00009892149,0.0001945734,0.00004788615,0.0001731497,0.0000626866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002888369,"about_ca_system_score_gemma":0.00008659958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003454328,"about_ca_topic_score_gemma":0.00002455287,"domain_scores_codex":[0.9982454,0.00008165435,0.0003929434,0.0004677157,0.0005293147,0.0002829946],"domain_scores_gemma":[0.9990376,0.00006856248,0.0001699429,0.0004115931,0.0001668716,0.0001454004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002642637,0.0003104194,0.01521742,0.0002858559,0.0001653629,0.000006988171,0.0002524162,0.000006519073,0.9765545,0.00003333039,0.00008064351,0.00682226],"study_design_scores_gemma":[0.003073793,0.001115372,0.00124087,0.00009160301,0.0002167074,0.00001270333,0.0002581998,0.00008016168,0.9876751,0.0000931124,0.005962226,0.0001801794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923287,0.004958855,0.00003895108,0.00004196897,0.0005167989,0.001529396,0.00002683313,0.00006010733,0.0004983966],"genre_scores_gemma":[0.9924983,0.0002456993,0.001169311,0.00003285448,0.0008330608,0.00008452524,0.00006942443,0.00004686211,0.005019975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01397655,"threshold_uncertainty_score":0.9999313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414054077781971,"score_gpt":0.2921499308567681,"score_spread":0.2680093900789484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}