{"id":"W2981314464","doi":"10.1016/j.omtn.2019.10.011","title":"A U1i RNA that Enhances HIV-1 RNA Splicing with an Elongated Recognition Domain Is an Optimal Candidate for Combination HIV-1 Gene Therapy","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Polyadenylation; RNA; RNA splicing; Long non-coding RNA; Biology; Small hairpin RNA; RNA interference; Non-coding RNA; DNA-directed RNA interference; Gene; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002302438,0.0003745118,0.0004686478,0.000181578,0.0001850879,0.0003559983,0.0002136424,0.0004600793,0.0009683948],"category_scores_gemma":[0.0002045662,0.0001323809,0.0002958874,0.0001542558,0.0002413658,0.0002606768,0.0001901263,0.0005809731,0.0004047974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002575394,"about_ca_system_score_gemma":0.0001452581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001532439,"about_ca_topic_score_gemma":0.0002187648,"domain_scores_codex":[0.999845,0.00003556282,0.00001527557,0.00003417767,0.00004183285,0.00002814324],"domain_scores_gemma":[0.9998851,0.00002411378,0.00004443043,0.00001337067,0.00001222829,0.00002070345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001279636,0.00005823387,0.000237361,0.00005434608,0.000006433309,0.00007655274,0.00001184999,0.0005010964,0.9922388,0.0003806085,0.00004599979,0.006260803],"study_design_scores_gemma":[0.00002241298,0.001055032,0.0008087383,0.000007425368,0.00002252344,0.0003232998,0.000009997719,0.001187794,0.9926378,0.00008886903,0.003825094,0.00001122041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592025,0.00606918,0.0303804,0.000232374,0.00007855466,0.0001687667,0.000212631,0.0001682576,0.003487325],"genre_scores_gemma":[0.9704458,0.001985622,0.02512726,0.0001351348,0.00002939694,0.00009358744,0.0002920763,0.00003279362,0.001858343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009683948,"threshold_uncertainty_score":0.003239632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515109169023707,"score_gpt":0.2474005373279083,"score_spread":0.2322494456376712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}