{"id":"W2981371759","doi":"10.1200/cci.19.00086","title":"Impact of Increasing Wait Times on Overall Mortality of Chimeric Antigen Receptor T-Cell Therapy in Large B-Cell Lymphoma: A Discrete Event Simulation Model","year":2019,"lang":"en","type":"article","venue":"JCO Clinical Cancer Informatics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Guelph; University of Waterloo","funders":"","keywords":"Chimeric antigen receptor; Medicine; Lymphoma; Refractory (planetary science); Chemotherapy; Internal medicine; Oncology; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001666291,0.0009913921,0.001204302,0.0008547674,0.0006005249,0.001388455,0.001451188,0.001942691,0.003471692],"category_scores_gemma":[0.00485327,0.0005509416,0.001625335,0.000605711,0.001014949,0.0006593679,0.00100882,0.001571054,0.0001993632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00246144,"about_ca_system_score_gemma":0.002515057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05389485,"about_ca_topic_score_gemma":0.01914341,"domain_scores_codex":[0.9993021,0.0003244362,0.00002749816,0.00009340814,0.00006377881,0.0001887973],"domain_scores_gemma":[0.9943259,0.004292058,0.0005539359,0.00009219684,0.0003666517,0.0003693265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00008361757,0.00005224461,0.002087912,0.00001101607,0.00002101541,0.00004559616,0.0000104371,0.9965885,0.00008844756,0.0006077422,0.0000805235,0.0003230541],"study_design_scores_gemma":[0.00004785194,0.00005234129,0.0003774938,0.00000351221,0.00001917941,0.000005518773,0.00001934252,0.999068,0.00006628667,0.0002752644,0.00006021016,0.000005052829],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9470569,0.0003691467,0.04181061,0.001193799,0.00008607635,0.0001938647,0.001538339,0.0001556129,0.007595692],"genre_scores_gemma":[0.9933696,0.0001622828,0.00390814,0.00009126395,0.00001213496,0.0001533243,0.0004543518,0.000009772399,0.001839326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05389485,"threshold_uncertainty_score":0.1071623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06868740518263323,"score_gpt":0.4467243361099316,"score_spread":0.3780369309272984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}