{"id":"W2981371759","doi":"10.1200/cci.19.00086","title":"Impact of Increasing Wait Times on Overall Mortality of Chimeric Antigen Receptor T-Cell Therapy in Large B-Cell Lymphoma: A Discrete Event Simulation Model","year":2019,"lang":"en","type":"article","venue":"JCO Clinical Cancer Informatics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Guelph; University of Waterloo","funders":"","keywords":"Chimeric antigen receptor; Medicine; Lymphoma; Refractory (planetary science); Chemotherapy; Internal medicine; Oncology; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001786195,0.0002368674,0.0008969444,0.0001788658,0.00002267601,0.00001350596,0.0002011496,0.0002256881,0.001264048],"category_scores_gemma":[0.0001600388,0.0001779144,0.000495483,0.0003155301,0.00008621507,0.0002186557,0.0000810721,0.0003451752,0.00003260943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000320714,"about_ca_system_score_gemma":0.0007530684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006915594,"about_ca_topic_score_gemma":0.00001359763,"domain_scores_codex":[0.9966961,0.0001652395,0.001777364,0.0001869842,0.0007801326,0.0003941883],"domain_scores_gemma":[0.9976256,0.0006143359,0.0007381924,0.0006353062,0.0002150748,0.0001714336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.007114823,0.003104666,0.8673389,0.0005723882,0.0002406115,0.000001039028,0.002029271,0.1010959,0.0059487,0.00002214929,0.000180666,0.01235094],"study_design_scores_gemma":[0.01408771,0.001999613,0.2883282,0.0002407191,0.00003170048,4.359056e-7,0.00008729546,0.6925398,0.002206745,0.00004660133,0.0002434551,0.0001877757],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937232,0.0001583104,0.0002072158,0.00002263738,0.00009934947,0.001119775,0.0001346989,0.00001870203,0.004516088],"genre_scores_gemma":[0.9967716,0.001818123,0.0004576536,0.0002257906,0.00007123143,0.00001374721,0.00007647261,0.00003361005,0.0005318225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5914439,"threshold_uncertainty_score":0.9996489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06868740518263323,"score_gpt":0.4467243361099316,"score_spread":0.3780369309272984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}