{"id":"W2981372844","doi":"10.1128/jvi.01325-19","title":"A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Uniformed Services University of the Health Sciences; National Institute of General Medical Sciences; amfAR, The Foundation for AIDS Research; Brookhaven National Laboratory; U.S. Department of Defense; U.S. Department of Energy; Office of Science; Canada Research Chairs; National Institutes of Health; Government of Canada","keywords":"Epitope; Antibody-dependent cell-mediated cytotoxicity; Glycoprotein; Antibody; Biology; Small molecule; Viral envelope; Virology; Trimer; Virus; Protein structure; Human immunodeficiency virus (HIV); Cell biology; Cytotoxicity; Biochemistry; In vitro; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082302,0.0003382558,0.0002965649,0.0002682288,0.0001995323,0.0002078577,0.0002978818,0.0002791069,0.001139138],"category_scores_gemma":[0.0001181219,0.00007776543,0.0001873067,0.0001074768,0.000229438,0.0002644854,0.0001976937,0.0005258684,0.0003788516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001977286,"about_ca_system_score_gemma":0.0001098711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001547187,"about_ca_topic_score_gemma":0.0002778945,"domain_scores_codex":[0.9999412,0.00001020903,0.000003339831,0.00001294949,0.00001958364,0.00001269608],"domain_scores_gemma":[0.9999452,0.000012705,0.00001282505,0.000003489105,0.000006437645,0.0000193003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006100605,0.0003868793,0.0009422368,0.0003253352,0.00005155838,0.0005270492,0.00005719742,0.0006282902,0.8882278,0.001751359,0.001697534,0.1047946],"study_design_scores_gemma":[0.0005179603,0.007633498,0.005009239,0.00003956654,0.0001036443,0.003499777,0.00004687852,0.001845698,0.8763368,0.0005497523,0.1043774,0.0000398417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.915677,0.04934758,0.01830493,0.0007678462,0.0003292875,0.0004146364,0.0006674565,0.0003433338,0.01414791],"genre_scores_gemma":[0.9476699,0.01863324,0.02104681,0.0007259757,0.0001852258,0.0002917703,0.000848495,0.00002672296,0.01057184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001139138,"threshold_uncertainty_score":0.003810763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398152712170404,"score_gpt":0.2472181555494432,"score_spread":0.2332366284277391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}