{"id":"W2981467520","doi":"10.3390/nu11112554","title":"Docosahexaenoic Acid Inhibits PTP1B Phosphatase and the Viability of MCF-7 Breast Cancer Cells","year":2019,"lang":"en","type":"article","venue":"Nutrients","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Allard Foundation; Natural Sciences and Engineering Research Council of Canada; Ministerstwo Edukacji i Nauki; Alberta Cancer Foundation","keywords":"Docosahexaenoic acid; MCF-7; Biochemistry; Phosphatase; Breast cancer; Allosteric regulation; Alkaline phosphatase; Cancer; Chemistry; Enzyme; Cancer research; Polyunsaturated fatty acid; Biology; Pharmacology; Fatty acid; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002313989,0.0001525674,0.0002001104,0.00001699176,0.00004648785,0.00001542118,0.0002211169,0.00009135342,0.00008482636],"category_scores_gemma":[0.00004134162,0.0001077782,0.00006628533,0.0001026878,0.0002471208,0.000007588941,0.0002425801,0.00007945313,0.00001781492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001339895,"about_ca_system_score_gemma":0.00005300482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001736034,"about_ca_topic_score_gemma":0.00001082067,"domain_scores_codex":[0.9989889,0.0000670431,0.0002167407,0.0003477721,0.0001671807,0.0002124018],"domain_scores_gemma":[0.9991534,0.00001951554,0.000130643,0.0005269179,0.00009880366,0.00007071842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003304853,0.0004321866,0.07299399,0.0003156373,0.0001517972,0.000001921399,0.0001124638,0.00002405533,0.9060715,0.002383008,0.005483411,0.008725125],"study_design_scores_gemma":[0.003006301,0.00008013468,0.006821181,0.00003131193,0.00002303993,0.000004944688,0.00001390216,0.00001302845,0.9832853,0.0001830565,0.006412226,0.0001255412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801909,0.01733405,0.00002873827,0.0002220033,0.0001974315,0.0007906965,0.001141129,0.000007504435,0.00008758848],"genre_scores_gemma":[0.998778,0.0005329756,0.00007967465,0.0002639272,0.00006262762,0.00006344584,0.0001129025,0.00001522081,0.00009121709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07721379,"threshold_uncertainty_score":0.4395069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003396966369374007,"score_gpt":0.2165010940533897,"score_spread":0.2131041276840157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}