{"id":"W2981467520","doi":"10.3390/nu11112554","title":"Docosahexaenoic Acid Inhibits PTP1B Phosphatase and the Viability of MCF-7 Breast Cancer Cells","year":2019,"lang":"en","type":"article","venue":"Nutrients","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Allard Foundation; Natural Sciences and Engineering Research Council of Canada; Ministerstwo Edukacji i Nauki; Alberta Cancer Foundation","keywords":"Docosahexaenoic acid; MCF-7; Biochemistry; Phosphatase; Breast cancer; Allosteric regulation; Alkaline phosphatase; Cancer; Chemistry; Enzyme; Cancer research; Polyunsaturated fatty acid; Biology; Pharmacology; Fatty acid; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006833777,0.0002805248,0.0003293087,0.000125676,0.0001676288,0.0002400352,0.0001983165,0.0001976537,0.001781996],"category_scores_gemma":[0.0001421189,0.00009700434,0.0005031468,0.0001819135,0.00009991069,0.00009232969,0.0001444511,0.000247062,0.000354264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004286787,"about_ca_system_score_gemma":0.0003086757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007797282,"about_ca_topic_score_gemma":0.006598552,"domain_scores_codex":[0.9999361,0.000007099467,0.000004640824,0.00001208948,0.00002467812,0.00001533302],"domain_scores_gemma":[0.9999695,0.000008576514,0.000007728575,0.00000253982,0.000006779859,0.000004847686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001402205,0.0002319424,0.009632076,0.0008861582,0.0002364431,0.0002208778,0.00004441287,0.03055508,0.9342303,0.0009678198,0.000811823,0.02078089],"study_design_scores_gemma":[0.0001156453,0.001245735,0.01854256,0.00006283292,0.0003497557,0.0002329389,0.0001528174,0.07443243,0.8908474,0.0005161955,0.0134612,0.00004063687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860328,0.005695883,0.003298606,0.0001271468,0.00003836099,0.0000134726,0.001372239,0.00008812521,0.003333484],"genre_scores_gemma":[0.9926703,0.002630586,0.001868513,0.00003200064,0.000003173341,0.00001586003,0.001247079,0.00001011524,0.001522424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007797282,"threshold_uncertainty_score":0.01550376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003396966369374007,"score_gpt":0.2165010940533897,"score_spread":0.2131041276840157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}