{"id":"W2981477552","doi":"10.1126/science.aav7188","title":"Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility","year":2019,"lang":"en","type":"article","venue":"Science","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":1417,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; NIHR Oxford Biomedical Research Centre; Menzies Centre for Australian Studies, King's College London, University of London; Medical Research Council; NIHR BioResource; Leonard M. Miller School of Medicine; National Institutes of Health; Sorbonne Université; UK Dementia Research Institute; National Institute on Aging; Menzies Institute for Medical Research; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Novo Nordisk Foundation Center for Basic Metabolic Research; Université de Lyon; Université de Nantes; Faculty of Health and Medical Sciences, University of Western Australia; Università degli Studi di Torino; Universidad Pública de Navarra; Université Claude Bernard Lyon 1; H. Lundbeck A/S; Hospital for Sick Children; Technische Universität München; Norges Forskningsråd; Rigshospitalet; King's College London; Centre National de la Recherche Scientifique; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Cambridge University Hospitals; KU Leuven; Fonds Wetenschappelijk Onderzoek; Yale University; Karolinska Institutet; AFA Försäkring; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Università degli Studi del Piemonte Orientale; Biogen; Agence Nationale de la Recherche; National Institute of General Medical Sciences; Johannes Gutenberg-Universität Mainz; University of Tasmania; Strategiske Forskningsråd; University of Cambridge; Children's Hospital of Philadelphia; Multiple Sclerosis Society; Vlaamse regering; National Institute for Health and Care Research; Keele University; Université de Lille; Novo Nordisk; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; University of Pennsylvania; Perelman School of Medicine, University of Pennsylvania; Vertex Pharmaceuticals; Lundbeckfonden; University College London; Wellcome Trust; Universitätsspital Zürich; Vanderbilt University; Westmead Millennium Institute for Medical Research; McGill University; Scleroseforeningen; Hospices Civils de Lyon; Universitetet i Oslo; Johns Hopkins University; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Broad Institute; European Commission; Menzies Research Institute Tasmania; Università degli Studi di Milano; University of Miami; Vanderbilt University Medical Center; Helsingin Yliopisto; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Harvard University; University of Oxford; Kaiser Permanente; National Multiple Sclerosis Society; Novo Nordisk Fonden; Case Western Reserve University; Harvard NeuroDiscovery Center","keywords":"Multiple sclerosis; Immune system; Major histocompatibility complex; Microglia; Biology; Gene; Immunology; Innate immune system; Genetics; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003123492,0.0001904789,0.0004052681,0.001376248,0.0003311176,0.000336941,0.0001682658,0.0001910633,0.001542461],"category_scores_gemma":[0.0008250122,0.0001120643,0.0002688814,0.001000319,0.0002232362,0.00008196831,0.000227657,0.0002041299,0.0002054644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645389,"about_ca_system_score_gemma":0.0002269168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002810992,"about_ca_topic_score_gemma":0.003782202,"domain_scores_codex":[0.9997041,0.00006783987,0.00001837046,0.0001065552,0.00006124147,0.00004192771],"domain_scores_gemma":[0.999582,0.0001694019,0.00008535472,0.0000490672,0.0000489153,0.00006524668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002082383,0.00009346613,0.7057423,0.0001690785,0.0005263661,0.00226437,0.0007968364,0.002349581,0.2191298,0.001319725,0.0006476853,0.06487833],"study_design_scores_gemma":[0.00004051087,0.0001963679,0.9885458,0.0000199767,0.0001709043,0.001625557,0.0001338076,0.001067097,0.004897963,0.00112424,0.002165302,0.0000125773],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981788,0.0004243584,0.0007212039,0.00003171193,0.00000221231,0.000004174364,0.0002827613,0.0000124149,0.0003423601],"genre_scores_gemma":[0.9985389,0.0001611039,0.0006546088,0.00001170725,0.000007569958,0.000005337078,0.0004442783,0.000003901801,0.000172596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002810992,"threshold_uncertainty_score":0.005589306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131266755768728,"score_gpt":0.2138583285157323,"score_spread":0.2007316529388595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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