{"id":"W2981493597","doi":"10.1126/sciadv.aaw3113","title":"BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential","year":2019,"lang":"en","type":"article","venue":"Science Advances","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of General Medical Sciences","keywords":"Snail; Slug; Suppressor; Phosphorylation; Cancer research; Degradation (telecommunications); Cell biology; Biology; Chemistry; Cancer; Medicine; Internal medicine; Computer science; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002279811,0.0003960368,0.0003549483,0.0005726773,0.00020772,0.0003125952,0.0002439854,0.0002230199,0.003371443],"category_scores_gemma":[0.000124671,0.0001869921,0.0003995436,0.0001959351,0.0002358139,0.0002751492,0.0001766055,0.000611799,0.0006388117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004173957,"about_ca_system_score_gemma":0.0002628225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007997482,"about_ca_topic_score_gemma":0.002977946,"domain_scores_codex":[0.9998409,0.00002916709,0.00001353362,0.000023891,0.00004746501,0.00004504306],"domain_scores_gemma":[0.9999455,0.000007143803,0.00001407142,0.000007432674,0.000006904934,0.00001890452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004371913,0.00009537369,0.0002704406,0.0000845534,0.00002963346,0.00006460844,0.000007138933,0.0002221906,0.993932,0.000238571,0.000226062,0.004392198],"study_design_scores_gemma":[0.0001282247,0.0007534703,0.005990544,0.000007411334,0.00004256858,0.000475739,0.00002301737,0.001420335,0.9861709,0.0001206032,0.004855517,0.00001167172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976245,0.007986663,0.004532176,0.0006346243,0.0001828582,0.00006160377,0.0007619679,0.0002662652,0.009328845],"genre_scores_gemma":[0.9908564,0.001554892,0.002203313,0.0001247505,0.00002348006,0.00002934266,0.0004510907,0.0000244535,0.004732354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003371443,"threshold_uncertainty_score":0.01127863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00672549358292581,"score_gpt":0.2501045274350815,"score_spread":0.2433790338521557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}