{"id":"W2981494509","doi":"10.1101/816082","title":"Broad-Spectrum Antifungal Activities and Mechanism of Drimane Sesquiterpenoids","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Johnson Cancer Research Center, Kansas State University; National Institutes of Health; King Saud University; University of Missouri-Kansas City; Merck Sharp and Dohme; University of Kansas; Kansas IDeA Network of Biomedical Research Excellence; University of Nebraska Medical Center","keywords":"Corpus albicans; Candida albicans; Biology; Microbiology; Cryptococcus neoformans; Mutant; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009632766,0.0004083155,0.0002220136,0.0005204436,0.0001026992,0.0001712974,0.0001768448,0.0002004786,0.001783025],"category_scores_gemma":[0.00006504076,0.0001051545,0.000242457,0.0001895596,0.0001525551,0.0001988803,0.0001619179,0.0002274533,0.000325923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001253916,"about_ca_system_score_gemma":0.0001039281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004019593,"about_ca_topic_score_gemma":0.0006812192,"domain_scores_codex":[0.9999614,0.000007589516,0.000003629812,0.000006838344,0.00001010463,0.00001051887],"domain_scores_gemma":[0.9999517,0.000005099745,0.00001290562,0.000003730445,0.00001140743,0.00001513585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002147416,0.00004061315,0.0003739722,0.000160757,0.00001444512,0.0001430546,0.0000163278,0.0003063153,0.9928495,0.0001305505,0.00003639057,0.00571348],"study_design_scores_gemma":[0.00005797018,0.001494969,0.008375337,0.00003296898,0.00005298267,0.0004086729,0.00006369694,0.0005633334,0.9828446,0.0001477387,0.005941318,0.00001634889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983051,0.01041351,0.001786307,0.0001090857,0.00001889642,0.00008982093,0.000875083,0.00005016012,0.003606277],"genre_scores_gemma":[0.9919281,0.003454423,0.001278992,0.00007817292,0.0000110792,0.00003268368,0.0005284335,0.000005278507,0.00268277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001783025,"threshold_uncertainty_score":0.005964756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186407430982401,"score_gpt":0.233203596251164,"score_spread":0.22133952194134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}