{"id":"W2981502437","doi":"10.1093/eurheartj/ehz746.0015","title":"4945Inclisiran-mediated reductions in Lp(a) in the ORION-1 trial","year":2019,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; PCSK9; LDL receptor; Internal medicine; Statin; Gastroenterology; Endocrinology; Cholesterol; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001124389,0.0006533039,0.001276253,0.0001522548,0.0001850021,0.0008444815,0.0003124558,0.000702857,0.00417449],"category_scores_gemma":[0.0009410747,0.0001845009,0.0009973191,0.0002476481,0.000304214,0.000427029,0.000295652,0.001390649,0.0005074745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002654071,"about_ca_system_score_gemma":0.0002645734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002209263,"about_ca_topic_score_gemma":0.0005823006,"domain_scores_codex":[0.9994637,0.0002762788,0.00004254263,0.00009248835,0.00005189136,0.00007299676],"domain_scores_gemma":[0.9996722,0.00008775177,0.00009300487,0.0000314547,0.00002831734,0.00008728579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8639414,0.002879849,0.01513353,0.002691855,0.004048883,0.0002048748,0.0001165172,0.0007190559,0.01709024,0.0006404351,0.006052783,0.08648068],"study_design_scores_gemma":[0.6863473,0.1454567,0.1362365,0.0007189602,0.009546929,0.0004294582,0.0001224027,0.001875603,0.005359979,0.001173335,0.01263934,0.00009348172],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771022,0.01353036,0.000418815,0.0005584671,0.0002311807,0.0004764691,0.0009758527,0.00007268452,0.006634017],"genre_scores_gemma":[0.9900904,0.003143655,0.0006644226,0.0007902473,0.0003569507,0.0005584218,0.001526524,0.00001886052,0.002850553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00417449,"threshold_uncertainty_score":0.01396507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04125482580301087,"score_gpt":0.3095414082840534,"score_spread":0.2682865824810425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}