{"id":"W2981566633","doi":"10.18632/oncotarget.27040","title":"Tris DBA palladium is an orally available inhibitor of GNAQ mutant uveal melanoma <i>in vivo</i>","year":2019,"lang":"en","type":"article","venue":"Oncotarget","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"GNAQ; Melanoma; Neuroblastoma RAS viral oncogene homolog; Cancer research; Medicine; In vivo; Mutant; Cancer; Mutation; Biology; Internal medicine; KRAS; Gene; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160633,0.0005205775,0.0003017575,0.000270811,0.0001959946,0.0003755551,0.0003117459,0.0002795319,0.004374849],"category_scores_gemma":[0.0001097735,0.0002117722,0.0003021323,0.0001462557,0.0001943979,0.0001994049,0.0001533906,0.0006744315,0.001403325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004991331,"about_ca_system_score_gemma":0.0003865768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001300834,"about_ca_topic_score_gemma":0.001778612,"domain_scores_codex":[0.9999006,0.00001454943,0.000007601137,0.00001781406,0.00002676238,0.00003255179],"domain_scores_gemma":[0.999944,0.000007314443,0.00001121528,0.000005417065,0.000006565998,0.00002555415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001551954,0.00030806,0.0002276693,0.0002078103,0.00003811105,0.0001630269,0.00002468127,0.0001941006,0.9837726,0.0003348932,0.001986887,0.01119024],"study_design_scores_gemma":[0.0004159196,0.003766803,0.003033859,0.00003330546,0.00005391743,0.000789671,0.00006177579,0.001619133,0.9758188,0.0002185422,0.01417075,0.00001753886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559297,0.0103115,0.004983232,0.001212872,0.0006225251,0.0001566,0.001095302,0.0009728119,0.0247155],"genre_scores_gemma":[0.974394,0.004988321,0.001917544,0.0004115863,0.00006499162,0.0000844507,0.001611595,0.0001189247,0.01640842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004374849,"threshold_uncertainty_score":0.01463538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370933166555915,"score_gpt":0.2619826094696406,"score_spread":0.2482732778040815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}