{"id":"W2981573144","doi":"10.3389/fimmu.2019.02481","title":"Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Deutsche Forschungsgemeinschaft","keywords":"Citrullination; Neutrophil extracellular traps; Calpain; Cell biology; Chromatin; Proteolysis; Chemistry; Extracellular; Histone; Calcium; Biochemistry; Citrulline; Biology; Inflammation; Arginine; Immunology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002998987,0.0003778034,0.000222571,0.0001978368,0.0002227139,0.0004353725,0.0002581774,0.0005368712,0.001828336],"category_scores_gemma":[0.0002248089,0.0001447182,0.0002876933,0.00008536449,0.0003972029,0.0003901467,0.0004548045,0.0005697857,0.0003563043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003679254,"about_ca_system_score_gemma":0.0002089592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002430314,"about_ca_topic_score_gemma":0.0004882689,"domain_scores_codex":[0.9997849,0.0000359165,0.00001762088,0.00004164647,0.00004884816,0.00007107054],"domain_scores_gemma":[0.9998435,0.000026597,0.00005641679,0.00001858019,0.00001756468,0.00003744745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002219922,0.00002699901,0.000415555,0.00008176027,0.00000672347,0.0002265516,0.00002887973,0.00006672175,0.9965131,0.0005488936,0.0001016245,0.001761125],"study_design_scores_gemma":[0.00005133271,0.0003384349,0.009654274,0.00002251408,0.00001136753,0.0009998727,0.00007146817,0.000936321,0.9825817,0.0005480395,0.004776515,0.000008153974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624332,0.0166044,0.01379916,0.0007167206,0.0001862346,0.00009529118,0.00028105,0.0001854416,0.00569853],"genre_scores_gemma":[0.9919208,0.001646769,0.003532224,0.0001178415,0.00003042512,0.00003556691,0.0001616044,0.00001066343,0.002544236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001828336,"threshold_uncertainty_score":0.00611639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00840168441299028,"score_gpt":0.2129808220125903,"score_spread":0.2045791375996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}