{"id":"W2981573144","doi":"10.3389/fimmu.2019.02481","title":"Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Deutsche Forschungsgemeinschaft","keywords":"Citrullination; Neutrophil extracellular traps; Calpain; Cell biology; Chromatin; Proteolysis; Chemistry; Extracellular; Histone; Calcium; Biochemistry; Citrulline; Biology; Inflammation; Arginine; Immunology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004523839,0.000292627,0.0005611152,0.0009921103,0.00007964,0.00001837006,0.0003752359,0.0004945821,0.0005244018],"category_scores_gemma":[0.00006863006,0.0003045402,0.00009113952,0.0005157883,0.0001120147,0.0003295254,0.0001028067,0.0005735498,0.001356052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002698237,"about_ca_system_score_gemma":0.00005209661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009699733,"about_ca_topic_score_gemma":0.0001024288,"domain_scores_codex":[0.9976141,0.0005342157,0.0006156382,0.0005160355,0.00005005616,0.0006699811],"domain_scores_gemma":[0.9992354,0.00008923444,0.0001496432,0.0004326143,0.00006538423,0.00002773566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006578058,0.0001826009,0.005349954,0.00002229404,0.00006922351,0.00003933271,0.001545735,0.0001174247,0.9740426,0.004307944,0.001671106,0.01199398],"study_design_scores_gemma":[0.009686877,0.001588499,0.07055762,0.0002140616,0.00004100603,0.0001638434,0.005164189,0.0002637901,0.8158126,0.005605359,0.08972411,0.001178089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850357,0.004363671,0.005805227,0.0006833666,0.002764987,0.0008297596,0.00001629116,0.00006777433,0.0004332617],"genre_scores_gemma":[0.9953262,0.0002569726,0.001705265,0.0004589528,0.00002273462,0.00008897334,0.0001289421,0.00003631994,0.001975635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1582301,"threshold_uncertainty_score":0.9999407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00840168441299028,"score_gpt":0.2129808220125903,"score_spread":0.2045791375996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}