{"id":"W2981587242","doi":"10.1177/0192623319880445","title":"Carcinogenicity Assessment of Daprodustat (GSK1278863), a Hypoxia-Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor","year":2019,"lang":"en","type":"article","venue":"Toxicologic Pathology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Carcinogen; Hypoxia (environmental); Hypoxia-inducible factors; Toxicity; Medicine; Erythropoietin; Internal medicine; Exacerbation; Kidney; Endocrinology; Pharmacology; Chronic toxicity; Physiology; Biology; Chemistry; Gene; Biochemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000480767,0.000359243,0.0006552874,0.0001277604,0.00008351586,0.0000140477,0.0004267636,0.0005745292,0.0002924677],"category_scores_gemma":[0.000174564,0.0003228857,0.0002565421,0.0002080511,0.0002325648,0.00001085695,0.0003713905,0.0003176197,0.0000444223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005759039,"about_ca_system_score_gemma":0.0003859877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002509049,"about_ca_topic_score_gemma":0.00002736814,"domain_scores_codex":[0.9973351,0.0002877274,0.0005252406,0.0009573494,0.00024585,0.0006487003],"domain_scores_gemma":[0.9983113,0.00004063025,0.0003212993,0.001000659,0.0001537406,0.0001723117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001204769,0.0003292297,0.01413101,0.00004707325,0.00005679883,0.0000140861,0.00006285858,0.00008205132,0.9807633,0.0001756075,0.00147514,0.002742425],"study_design_scores_gemma":[0.002555763,0.002468925,0.1240824,0.00001290421,0.00007492977,0.0001496232,0.0001211353,0.00007425206,0.820982,0.0002024395,0.04872199,0.0005536253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911479,0.002135581,0.0003367708,0.0001448368,0.002491105,0.0007870105,0.000141731,0.00004055065,0.00277447],"genre_scores_gemma":[0.9947186,0.0004021144,0.001305839,0.0005851354,0.0009303745,0.00009610469,0.00009054632,0.00003850998,0.001832771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1597812,"threshold_uncertainty_score":0.9999223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870461920136723,"score_gpt":0.2824731570187174,"score_spread":0.2637685378173502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}