{"id":"W2981587242","doi":"10.1177/0192623319880445","title":"Carcinogenicity Assessment of Daprodustat (GSK1278863), a Hypoxia-Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor","year":2019,"lang":"en","type":"article","venue":"Toxicologic Pathology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Carcinogen; Hypoxia (environmental); Hypoxia-inducible factors; Toxicity; Medicine; Erythropoietin; Internal medicine; Exacerbation; Kidney; Endocrinology; Pharmacology; Chronic toxicity; Physiology; Biology; Chemistry; Gene; Biochemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002659358,0.0003660031,0.0002248263,0.000345909,0.0001611819,0.0001591785,0.0001436029,0.0003238777,0.001140234],"category_scores_gemma":[0.000187263,0.0001362204,0.0003425412,0.0002518844,0.000132906,0.0001287865,0.0001188012,0.0003786976,0.0001456159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002869112,"about_ca_system_score_gemma":0.0003860008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001230924,"about_ca_topic_score_gemma":0.0023152,"domain_scores_codex":[0.9998578,0.00004232727,0.000008083926,0.00003013619,0.00004071762,0.00002081964],"domain_scores_gemma":[0.9998093,0.00003342489,0.00005465054,0.00002012012,0.00004334232,0.00003901499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001531308,0.0003663017,0.004293867,0.000117686,0.00004659922,0.00009781686,0.00004110645,0.001066451,0.982788,0.00006442877,0.0001444738,0.009441834],"study_design_scores_gemma":[0.00009714338,0.02271699,0.0196762,0.000020973,0.0001752098,0.0004063231,0.00005784455,0.001329349,0.9528202,0.00005729274,0.002627747,0.00001473535],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99559,0.0008215716,0.001652271,0.00003289914,0.00001302377,0.0001206633,0.0007043013,0.00003458418,0.001030636],"genre_scores_gemma":[0.9940666,0.001390435,0.001682865,0.00003980471,0.000007516194,0.00007495968,0.0007839575,0.00001253584,0.001941328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001230924,"threshold_uncertainty_score":0.003814459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870461920136723,"score_gpt":0.2824731570187174,"score_spread":0.2637685378173502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}