{"id":"W2981595408","doi":"10.1186/s40425-019-0762-2","title":"Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma","year":2019,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Pediatric Oncology Group","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; EMD Serono; Eisai; Servier; Amgen; Pfizer; Daiichi Sankyo Europe; Eli Lilly and Company; Eurostars; GlaxoSmithKline","keywords":"Medicine; T cell; Immunology; Fludarabine; Tumor microenvironment; Progressive disease; Synovial sarcoma; Cytotoxic T cell; Immune system; Cancer research; Internal medicine; Pathology; Sarcoma; Biology; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002162915,0.0002297079,0.000334205,0.0001393574,0.0001005954,0.0001646377,0.000107882,0.0001567124,0.0006482766],"category_scores_gemma":[0.0001879925,0.00009354417,0.0001839341,0.0000988559,0.0002139918,0.0001493044,0.000157569,0.0004849665,0.0001713614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001593137,"about_ca_system_score_gemma":0.0001583631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002845144,"about_ca_topic_score_gemma":0.0004487594,"domain_scores_codex":[0.9998747,0.0000295208,0.000009058523,0.00002418354,0.00002479401,0.00003766194],"domain_scores_gemma":[0.9998811,0.0000235242,0.00002698668,0.00001597789,0.000006404632,0.00004592997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01151073,0.002583775,0.01462436,0.0001038319,0.00005811337,0.0005418268,0.0001952963,0.001377159,0.9300939,0.0001034563,0.0004521825,0.0383555],"study_design_scores_gemma":[0.001798701,0.1430706,0.2194488,0.00003221348,0.0003253393,0.003881176,0.0004405497,0.006317065,0.6208394,0.000261326,0.003554866,0.00002982566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994195,0.0001482188,0.0001503087,0.00001163553,0.000005415706,0.00001385424,0.00002822779,0.000009555647,0.0002134153],"genre_scores_gemma":[0.9994355,0.00007825813,0.0001108359,0.00002020632,0.000008473102,0.00001793552,0.0000930958,0.000002746701,0.0002329143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006482766,"threshold_uncertainty_score":0.002168775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853585997131978,"score_gpt":0.3255511113769634,"score_spread":0.3070152514056436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}