{"id":"W2981694477","doi":"10.1126/science.aau6391","title":"Palmitoylation of NOD1 and NOD2 is required for bacterial sensing","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University Health Network; SickKids Foundation; University of Toronto; Princess Margaret Cancer Centre; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"NOD1; Palmitoylation; NOD2; Endosome; Cell biology; Intracellular; Biology; Signal transduction; Pattern recognition receptor; Nod; Chemistry; Receptor; Innate immune system; Biochemistry; Cysteine; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001772013,0.0003133842,0.0002492282,0.000185829,0.0002695226,0.0003237039,0.0002089721,0.000266056,0.001224973],"category_scores_gemma":[0.0002002877,0.0001822331,0.0002157183,0.0001435123,0.0002404307,0.0002014414,0.0005256697,0.0003778102,0.0007489449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004392781,"about_ca_system_score_gemma":0.0003042302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007672792,"about_ca_topic_score_gemma":0.00121016,"domain_scores_codex":[0.9997714,0.00004061315,0.00003334896,0.00004799892,0.00005565329,0.00005100452],"domain_scores_gemma":[0.9997177,0.000028078,0.000100268,0.00003075559,0.00002628528,0.00009698451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001988797,0.00001408499,0.0004766551,0.00002502697,0.000004217392,0.00009740736,0.00000964434,0.0000573232,0.9983398,0.00008281192,0.00004124432,0.0006529061],"study_design_scores_gemma":[0.00003477165,0.0001547339,0.02284583,0.00001064989,0.00001642918,0.0007241407,0.00006299047,0.001490024,0.9699011,0.000113365,0.00463525,0.0000106017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955064,0.001134876,0.001759944,0.0001236597,0.00002720706,0.00001260626,0.0004505783,0.00007408684,0.0009105667],"genre_scores_gemma":[0.9953656,0.0003491265,0.001149105,0.0000576031,0.000007659493,0.00001476417,0.001192093,0.00002483172,0.001839123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224973,"threshold_uncertainty_score":0.004097939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049207591499155,"score_gpt":0.245689018498768,"score_spread":0.2351969425837764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}