{"id":"W2981694477","doi":"10.1126/science.aau6391","title":"Palmitoylation of NOD1 and NOD2 is required for bacterial sensing","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University Health Network; SickKids Foundation; University of Toronto; Princess Margaret Cancer Centre; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"NOD1; Palmitoylation; NOD2; Endosome; Cell biology; Intracellular; Biology; Signal transduction; Pattern recognition receptor; Nod; Chemistry; Receptor; Innate immune system; Biochemistry; Cysteine; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003540138,0.00003582003,0.00007269428,0.00006322128,0.0000869857,0.00001016122,0.00005852756,0.00004531047,0.00004965284],"category_scores_gemma":[0.00008433901,0.00003115819,0.0000153213,0.00008903508,0.0001937371,0.0001932306,0.00002742649,0.00002252364,0.00004188293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009118557,"about_ca_system_score_gemma":0.00005845113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000706738,"about_ca_topic_score_gemma":5.711e-7,"domain_scores_codex":[0.9996225,0.00001942379,0.0001093112,0.0001171343,0.00002081586,0.0001108067],"domain_scores_gemma":[0.9997056,0.000045294,0.0000670226,0.0001044962,0.00007310772,0.000004495669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001061832,0.000002353227,0.0002807404,0.000008319655,0.000002757673,1.977237e-8,0.000419116,2.918719e-7,0.9911127,0.000203169,0.00002447257,0.007839853],"study_design_scores_gemma":[0.0004175212,0.00007008104,0.00973757,0.00001838168,0.000003610452,0.000005580774,0.00006926891,0.00009604516,0.9839167,0.0001064453,0.005517925,0.00004087322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985352,0.0001169487,0.0002133271,0.0001075977,0.0005969981,0.000143652,0.000002559864,0.000007091467,0.000276642],"genre_scores_gemma":[0.9992434,0.000006958418,0.0002434961,0.00002505484,0.000010791,6.253036e-7,0.00000580013,0.000001913113,0.0004619406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00945683,"threshold_uncertainty_score":0.1270594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049207591499155,"score_gpt":0.245689018498768,"score_spread":0.2351969425837764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}