{"id":"W2981703489","doi":"10.1101/373670","title":"Activated α <sub>IIb</sub> β <sub>3</sub> on platelets mediates flow-dependent NETosis via SLC44A2","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; Imperial College London; British Heart Foundation","keywords":"Mechanosensitive channels; Platelet; Neutrophil extracellular traps; Von Willebrand factor; Platelet activation; Immunology; Integrin; Population; Cell biology; Biology; Chemistry; Medicine; Inflammation; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120168,0.0001588881,0.000170226,0.0001152037,0.000115374,0.0002599038,0.00009364101,0.0002144354,0.002893019],"category_scores_gemma":[0.0001470029,0.00007414974,0.0002143295,0.00007449106,0.0001452738,0.00006577859,0.0001300549,0.0001755347,0.0003680949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001792081,"about_ca_system_score_gemma":0.0001336258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009547326,"about_ca_topic_score_gemma":0.0008860548,"domain_scores_codex":[0.9999053,0.00002891762,0.000008354619,0.00001468084,0.00002162088,0.00002113643],"domain_scores_gemma":[0.9998771,0.00001874044,0.00005143029,0.000008173028,0.00001376169,0.00003087029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003983523,0.00003537974,0.01119542,0.00005509059,0.00003650407,0.0007362349,0.00002629796,0.00009496514,0.9840641,0.0002672574,0.0006092195,0.002481243],"study_design_scores_gemma":[0.0001982886,0.001104193,0.4129474,0.00004998863,0.0002443451,0.01003676,0.0001886398,0.01107955,0.5494311,0.0008565147,0.01383788,0.00002539255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964275,0.0004993367,0.001036662,0.0002249395,0.00002522623,0.00001333664,0.0002581643,0.00005261886,0.001462274],"genre_scores_gemma":[0.9986233,0.0001334981,0.0003566139,0.00007516961,0.00001633765,0.000009710694,0.0001271032,0.0000066863,0.0006516239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002893019,"threshold_uncertainty_score":0.009678125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135090372151295,"score_gpt":0.2013736720820445,"score_spread":0.1900227683605315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}