{"id":"W2981731409","doi":"10.1016/j.nucmedbio.2019.10.001","title":"Effectiveness and normal tissue toxicity of Auger electron (AE) radioimmunotherapy (RIT) with [111In]In-Bn-DTPA-nimotuzumab in mice with triple-negative or trastuzumab-resistant human breast cancer xenografts that overexpress EGFR","year":2019,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network; Saskatoon Medical Imaging; University of Saskatchewan; Royal University Hospital","funders":"Canadian Breast Cancer Research Alliance","keywords":"Nimotuzumab; Trastuzumab; Radioimmunotherapy; Medicine; Toxicity; Saline; Cancer; Epidermal growth factor receptor; Internal medicine; Breast cancer; Pathology; Pharmacology; Chemistry; Monoclonal antibody; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917313,0.0002282995,0.0006679315,0.0001007566,0.00005191789,0.000004819841,0.00008214642,0.0001290071,0.0003119663],"category_scores_gemma":[0.00001116225,0.000134417,0.00002033223,0.0002653917,0.0005449028,0.00006239633,0.0000182416,0.0003469979,8.148336e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001074086,"about_ca_system_score_gemma":0.00007030603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104926,"about_ca_topic_score_gemma":0.0001987436,"domain_scores_codex":[0.9988326,0.00009882188,0.0002472366,0.0003951871,0.0001160908,0.0003100712],"domain_scores_gemma":[0.999355,0.0002038144,0.0001108168,0.000168587,0.00005276242,0.0001090164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01337903,0.0002221698,0.02788059,0.000447327,0.0001170109,0.00002547775,0.0007955266,0.000001876544,0.9550795,0.0002045984,0.00002805903,0.001818821],"study_design_scores_gemma":[0.02916568,0.00823293,0.6820484,0.001918435,0.0002024381,0.0005745709,0.001243336,0.00007812351,0.2736069,0.00006873735,0.002436,0.0004244415],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966774,0.001040337,0.000005259762,0.0009918802,0.00001882016,0.0007582989,0.00003046643,0.00001721188,0.0004603522],"genre_scores_gemma":[0.9988872,0.0005327396,0.00005815749,0.000275404,0.00007303553,0.00003941104,0.00001441239,0.00002479171,0.0000948668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6814726,"threshold_uncertainty_score":0.5481365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969679444872791,"score_gpt":0.3286435541212145,"score_spread":0.3089467596724866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}