{"id":"W2981731409","doi":"10.1016/j.nucmedbio.2019.10.001","title":"Effectiveness and normal tissue toxicity of Auger electron (AE) radioimmunotherapy (RIT) with [111In]In-Bn-DTPA-nimotuzumab in mice with triple-negative or trastuzumab-resistant human breast cancer xenografts that overexpress EGFR","year":2019,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network; Saskatoon Medical Imaging; University of Saskatchewan; Royal University Hospital","funders":"Canadian Breast Cancer Research Alliance","keywords":"Nimotuzumab; Trastuzumab; Radioimmunotherapy; Medicine; Toxicity; Saline; Cancer; Epidermal growth factor receptor; Internal medicine; Breast cancer; Pathology; Pharmacology; Chemistry; Monoclonal antibody; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005315504,0.0006089421,0.0004921362,0.0006096605,0.0002105512,0.0004405233,0.0004639741,0.0007630577,0.001454115],"category_scores_gemma":[0.0003095342,0.0002756544,0.0003621401,0.0002335702,0.0007019456,0.000585266,0.000157977,0.0008950023,0.0002260237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004553897,"about_ca_system_score_gemma":0.0003388814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001759883,"about_ca_topic_score_gemma":0.001316089,"domain_scores_codex":[0.9996582,0.000101393,0.00001617885,0.00006749036,0.000050455,0.0001062527],"domain_scores_gemma":[0.9997062,0.00009805981,0.00006868449,0.00004121023,0.00002160313,0.00006431784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006814185,0.0007419038,0.0007570417,0.00006886429,0.00006273957,0.0001471275,0.0000967474,0.001451786,0.98376,0.0006901798,0.0001942837,0.005215111],"study_design_scores_gemma":[0.000211208,0.007118659,0.004979105,0.000009284737,0.0001409916,0.0002891782,0.00004555109,0.005153013,0.980771,0.0001735765,0.001093589,0.000014854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994105,0.001443862,0.001586883,0.0001056667,0.0000453082,0.00003430107,0.0002385966,0.0001192061,0.00232119],"genre_scores_gemma":[0.9946699,0.0006692787,0.0007486293,0.00004049685,0.00001761642,0.00003969214,0.0002700617,0.00005291787,0.003491386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759883,"threshold_uncertainty_score":0.004864514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969679444872791,"score_gpt":0.3286435541212145,"score_spread":0.3089467596724866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}