{"id":"W2981795052","doi":"10.1002/pro.3759","title":"Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities","year":2019,"lang":"en","type":"article","venue":"Protein Science","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"PDZ domain; Biology; Mutation; Peptide; Ligand (biochemistry); Genetics; Computational biology; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002353305,0.000341608,0.0002817812,0.0005097557,0.0002332159,0.0002937677,0.0002058711,0.0002924736,0.0004770317],"category_scores_gemma":[0.0002664062,0.0001883262,0.0003014285,0.000392388,0.0002099063,0.0002502192,0.0004384078,0.0005796216,0.0001492848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002193347,"about_ca_system_score_gemma":0.0001904918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003038516,"about_ca_topic_score_gemma":0.0004207212,"domain_scores_codex":[0.9998723,0.00001954779,0.00001030134,0.0000343043,0.00003427816,0.00002918437],"domain_scores_gemma":[0.9998361,0.00005919269,0.00004159042,0.0000182208,0.00001824629,0.00002659523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002219891,0.0000347371,0.01160501,0.00004548646,0.00003914184,0.0003766042,0.00006806709,0.001212144,0.9784254,0.0002915647,0.0000192765,0.00766048],"study_design_scores_gemma":[0.00007768576,0.0009308232,0.3332408,0.00004612326,0.0003552373,0.006944153,0.000453943,0.02059524,0.6259754,0.001467274,0.009820184,0.00009320273],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970896,0.0002288114,0.002023327,0.00001290132,0.000001248088,0.00001144501,0.0001355814,0.00001494811,0.0004820584],"genre_scores_gemma":[0.9960541,0.000276177,0.002879116,0.00002918526,0.000001891489,0.00001563629,0.0004309521,0.00001615352,0.0002968262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005097557,"threshold_uncertainty_score":0.001595855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02279499840014578,"score_gpt":0.2783194329604177,"score_spread":0.2555244345602719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}