{"id":"W2981799902","doi":"10.3390/cancers11111646","title":"STAT3: An Emerging Therapeutic Target for Hepatocellular Carcinoma","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health and Medical Research Fund; Terry Fox Foundation","keywords":"STAT3; Hepatocellular carcinoma; Medicine; STAT protein; Cancer research; Targeted therapy; Clinical trial; Transcription factor; Metastasis; Cancer; Oncology; Internal medicine; Biology; Signal transduction; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002641028,0.0005222674,0.0006538779,0.001309047,0.0001760523,0.0004989114,0.0003871979,0.0006244727,0.003731197],"category_scores_gemma":[0.0002098577,0.0001361355,0.0004285259,0.0009771292,0.0002193998,0.0005808649,0.0003967026,0.001370099,0.001340885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003820793,"about_ca_system_score_gemma":0.0006634396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006622333,"about_ca_topic_score_gemma":0.001812733,"domain_scores_codex":[0.9999197,0.00001311519,0.00001064447,0.00001401149,0.00003086024,0.00001179116],"domain_scores_gemma":[0.9999231,0.00003106219,0.0000118545,0.00000222596,0.00002283874,0.000008927416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001074142,0.00008564658,0.0002011969,0.01312314,0.00008297092,0.0001843522,0.00004694429,0.0004294109,0.005025273,0.003473625,0.02509504,0.952145],"study_design_scores_gemma":[0.00003021596,0.0001800275,0.0009302614,0.001855742,0.0001346417,0.00100818,0.00004264536,0.0001905741,0.001360793,0.001889948,0.9923595,0.00001752754],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003222632,0.9979233,0.0001337791,0.0003243753,0.0001763331,0.000004532744,0.00003691875,0.00001103394,0.00106755],"genre_scores_gemma":[0.001682864,0.9968151,0.0001460648,0.0002958006,0.0001334018,0.000006605465,0.00007666658,0.000001698345,0.0008416416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003731197,"threshold_uncertainty_score":0.01248211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3763264120059471,"score_gpt":0.5037783466143937,"score_spread":0.1274519346084466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}