{"id":"W2981799902","doi":"10.3390/cancers11111646","title":"STAT3: An Emerging Therapeutic Target for Hepatocellular Carcinoma","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health and Medical Research Fund; Terry Fox Foundation","keywords":"STAT3; Hepatocellular carcinoma; Medicine; STAT protein; Cancer research; Targeted therapy; Clinical trial; Transcription factor; Metastasis; Cancer; Oncology; Internal medicine; Biology; Signal transduction; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003993119,0.0005603106,0.001348112,0.0001536032,0.0002706638,0.00003813005,0.0005648614,0.0005666934,0.00100747],"category_scores_gemma":[0.000009835477,0.0004924081,0.0006005183,0.0002027508,0.0001459701,0.0001113716,0.00006539428,0.0007776811,0.0001201121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00104446,"about_ca_system_score_gemma":0.001398714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003509356,"about_ca_topic_score_gemma":0.000004520875,"domain_scores_codex":[0.9976337,0.0003938836,0.0004773747,0.000681755,0.0001320746,0.0006812181],"domain_scores_gemma":[0.9986929,0.000202447,0.0003744046,0.0003842048,0.00009319462,0.0002528818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008855836,0.00006234677,0.0005861861,0.01392689,0.0009235599,0.00003622252,0.0001837293,0.00005226485,0.00004077885,0.0005772117,0.006346991,0.9771752],"study_design_scores_gemma":[0.0006051143,0.0002121017,0.000003721123,0.0004599334,0.001451712,0.00001071741,0.00005228486,0.002652972,0.00005681955,0.00008846492,0.9938256,0.0005806161],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004298045,0.991102,0.0003407291,0.00002484564,0.004485061,0.001885539,0.000785186,0.00007085672,0.0008759568],"genre_scores_gemma":[0.002890191,0.9925064,0.0001385434,0.0005639057,0.0007633762,0.0004297721,0.0005943704,0.0001290468,0.001984358],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9874786,"threshold_uncertainty_score":0.9999058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3763264120059471,"score_gpt":0.5037783466143937,"score_spread":0.1274519346084466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}