{"id":"W2981838232","doi":"10.3389/fnagi.2019.00297","title":"Genome-Wide Association Studies for Cerebrospinal Fluid Soluble TREM2 in Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Medpace; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Alzheimer's Association","keywords":"TREM2; Genome-wide association study; Neuroinflammation; Cerebrospinal fluid; Biomarker; Pathogenesis; Immunology; Disease; Dementia; Alzheimer's disease; Immune system; Medicine; Biology; Gene; Genetics; Internal medicine; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005274823,0.0002472023,0.0003239159,0.0004777897,0.0002260917,0.0001601751,0.0005142546,0.00004742816,0.000009466273],"category_scores_gemma":[0.003923743,0.0002552432,0.00009013257,0.0009123593,0.00008516368,0.0007359209,0.0001213595,0.0002213456,0.00002882782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002284889,"about_ca_system_score_gemma":0.0001180567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002021158,"about_ca_topic_score_gemma":0.00000545003,"domain_scores_codex":[0.9970074,0.0002410006,0.000490653,0.001029521,0.000584483,0.0006469726],"domain_scores_gemma":[0.9987084,0.0004841973,0.0002419506,0.0003661117,0.00005564183,0.0001436779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001102082,0.0001233862,0.1567382,0.00004979277,0.000002146879,0.00003976482,0.0004295236,0.01041348,0.8273238,0.0009709145,0.003480745,0.0003180823],"study_design_scores_gemma":[0.004144283,0.0004167147,0.1868888,0.0001356951,0.0000406941,0.000007622195,0.0003068189,0.1815565,0.5932487,0.005836166,0.02612872,0.001289258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976287,0.0002921112,0.007129782,0.004841126,0.009439521,0.001596632,0.00002090293,0.0001805898,0.0002123017],"genre_scores_gemma":[0.9884479,0.0002458624,0.0009694938,0.007758504,0.00006466478,0.0001257573,0.000003182465,0.00003672288,0.002347879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2340751,"threshold_uncertainty_score":0.99999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04890758809972186,"score_gpt":0.2906266589171608,"score_spread":0.2417190708174389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}