{"id":"W2981838232","doi":"10.3389/fnagi.2019.00297","title":"Genome-Wide Association Studies for Cerebrospinal Fluid Soluble TREM2 in Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Medpace; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Alzheimer's Association","keywords":"TREM2; Genome-wide association study; Neuroinflammation; Cerebrospinal fluid; Biomarker; Pathogenesis; Immunology; Disease; Dementia; Alzheimer's disease; Immune system; Medicine; Biology; Gene; Genetics; Internal medicine; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00128484,0.0004662461,0.0004678908,0.001201847,0.000467151,0.0005525748,0.0003348384,0.0005977557,0.002762825],"category_scores_gemma":[0.002343965,0.0002184813,0.00133295,0.001557336,0.000286663,0.0002795289,0.0004933672,0.0005846011,0.0002227958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344996,"about_ca_system_score_gemma":0.0002226797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002196788,"about_ca_topic_score_gemma":0.002965809,"domain_scores_codex":[0.9992331,0.0002289552,0.00009083407,0.0002807088,0.0000923771,0.0000738897],"domain_scores_gemma":[0.9987429,0.0004401967,0.000394407,0.0001163527,0.0001313361,0.0001748295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001800201,0.00008255621,0.9754152,0.0001735548,0.003980849,0.001260319,0.0001557759,0.0002816106,0.008980518,0.0002012037,0.0007457745,0.006922334],"study_design_scores_gemma":[0.00005093673,0.00008710928,0.9964526,0.00001824326,0.0009792404,0.0007444661,0.00006686892,0.0004129046,0.0003778255,0.0001872799,0.0006130493,0.000009507521],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948606,0.003218999,0.0005031129,0.0001894493,0.0000479201,0.000006962098,0.0006293873,0.00001873924,0.0005248436],"genre_scores_gemma":[0.9981366,0.0006045843,0.000418189,0.00006831111,0.0000444905,0.000009242364,0.0004545708,0.00000804137,0.0002559416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002762825,"threshold_uncertainty_score":0.009242594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04890758809972186,"score_gpt":0.2906266589171608,"score_spread":0.2417190708174389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}