{"id":"W2981851713","doi":"10.1016/j.jnutbio.2019.108243","title":"CD8+ T cell/adipocyte inflammatory cross talk and ensuing M1 macrophage polarization are reduced by fish-oil-derived n-3 polyunsaturated fatty acids, in part by a TNF-α-dependent mechanism","year":2019,"lang":"en","type":"article","venue":"The Journal of Nutritional Biochemistry","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Fish oil; Polyunsaturated fatty acid; Chemistry; Macrophage polarization; Mechanism (biology); Tumor necrosis factor alpha; Macrophage; Adipocyte; Inflammation; Fish <Actinopterygii>; Cell biology; Biochemistry; Immunology; Biology; Fatty acid; In vitro; Adipose tissue; Fishery; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004092258,0.0002415863,0.0003696433,0.00008537895,0.0001306681,0.00005839282,0.0001721511,0.000186342,0.0001396483],"category_scores_gemma":[0.00016223,0.0001948398,0.0001050947,0.0001602754,0.0001151155,0.0002147382,0.00004245358,0.0003997951,0.000005393693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001191417,"about_ca_system_score_gemma":0.0001906221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001163925,"about_ca_topic_score_gemma":0.000001163107,"domain_scores_codex":[0.9982101,0.00009326467,0.0006711117,0.0002112154,0.0005483676,0.0002659095],"domain_scores_gemma":[0.9984692,0.0001033051,0.0006177991,0.0002111226,0.0003620604,0.0002365325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008383254,0.0002378797,0.003362078,0.0003980872,0.0000758438,0.00005020751,0.00007897902,0.000007887169,0.9938071,0.000005530399,0.001018261,0.0001198501],"study_design_scores_gemma":[0.004584183,0.00005641278,0.01738145,0.000667352,0.0001468994,0.0005526391,0.0003312806,0.00003563963,0.9749851,0.00006999746,0.0009846073,0.0002044094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935593,0.004845425,0.00002933864,0.0006965194,0.0001587092,0.0001774564,0.000382639,0.00001978244,0.0001308523],"genre_scores_gemma":[0.9958285,0.001772827,0.0001022404,0.0003446467,0.00034377,0.000007035457,0.0003569766,0.00002747807,0.001216506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01882194,"threshold_uncertainty_score":0.7945336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005918049192206779,"score_gpt":0.224972724830654,"score_spread":0.2190546756384472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}