{"id":"W2981860386","doi":"10.2147/dddt.s207856","title":"<p>Cardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis</p>","year":2019,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Swedish Orphan Biovitrum; JCR Pharmaceuticals; Amicus Therapeutics; Alexion Pharmaceuticals; Ultragenyx Pharmaceutical; Sanofi; Idorsia Pharmaceuticals; Shire Human Genetic Therapies; GlaxoSmithKline","keywords":"Medicine; Renal function; Internal medicine; Cohort; Urology; Left ventricular hypertrophy; Fabry disease; Cardiology; Endocrinology; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00274261,0.00065596,0.001325115,0.0006648843,0.0002350235,0.000180082,0.0003651839,0.0001808914,0.001817671],"category_scores_gemma":[0.00006476483,0.0004459863,0.0002742689,0.001090697,0.0001384075,0.0002010971,0.0001031349,0.0003119555,0.000279397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002315803,"about_ca_system_score_gemma":0.0004725668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004876595,"about_ca_topic_score_gemma":0.0001355489,"domain_scores_codex":[0.9952362,0.0006008951,0.0007730518,0.00102787,0.001509811,0.000852157],"domain_scores_gemma":[0.997757,0.0003669741,0.0002381545,0.0009001592,0.0003408366,0.0003969359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006109332,0.0004515485,0.9603968,0.0000474662,0.005530973,0.0001424882,0.001689146,0.00002100154,0.003277321,0.00001600309,0.001428776,0.02088909],"study_design_scores_gemma":[0.01198721,0.0006399762,0.96661,0.00006697819,0.0001514078,0.00001780369,0.00007403437,0.00008392533,0.007363636,0.00001138979,0.01224827,0.0007454305],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889394,0.00411423,0.003256269,0.0003890251,0.00008998114,0.00210905,0.00001389116,0.0001315167,0.0009566574],"genre_scores_gemma":[0.9672129,0.00134337,0.001975327,0.0005490155,0.00005142164,0.0001877895,0.0003136108,0.0001037594,0.02826276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02730611,"threshold_uncertainty_score":0.9997992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04332455212688859,"score_gpt":0.2955784045651831,"score_spread":0.2522538524382946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}