{"id":"W2981860386","doi":"10.2147/dddt.s207856","title":"<p>Cardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis</p>","year":2019,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Swedish Orphan Biovitrum; JCR Pharmaceuticals; Amicus Therapeutics; Alexion Pharmaceuticals; Ultragenyx Pharmaceutical; Sanofi; Idorsia Pharmaceuticals; Shire Human Genetic Therapies; GlaxoSmithKline","keywords":"Medicine; Renal function; Internal medicine; Cohort; Urology; Left ventricular hypertrophy; Fabry disease; Cardiology; Endocrinology; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002567123,0.0002815108,0.0002632629,0.0005911542,0.0001412324,0.0005727414,0.0002506499,0.0002444819,0.0009135794],"category_scores_gemma":[0.002371368,0.0001065212,0.0009039492,0.0008107423,0.0002062967,0.0005222975,0.0004811851,0.0004322343,0.0001976892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005902697,"about_ca_system_score_gemma":0.0006013136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00410343,"about_ca_topic_score_gemma":0.004834787,"domain_scores_codex":[0.9992692,0.0003491309,0.00007356674,0.00009990965,0.0001229975,0.00008509366],"domain_scores_gemma":[0.9979722,0.0003125533,0.001193363,0.00009074609,0.0001928009,0.0002383254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00252952,0.00008197035,0.9799179,0.00009373654,0.0009307944,0.00006478529,0.00005359142,0.0004207143,0.0002670244,0.00008038014,0.002175699,0.01338378],"study_design_scores_gemma":[0.0002390888,0.0009084832,0.9946879,0.00003512416,0.0006545506,0.0001502882,0.00008693826,0.00120429,0.0003101078,0.00009643658,0.001618496,0.000008301497],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907287,0.000772551,0.0008985668,0.0003600815,0.0000184136,0.00009110149,0.006228866,0.00001997219,0.0008816051],"genre_scores_gemma":[0.9945714,0.0001988567,0.0004454805,0.0001385409,0.00002581312,0.0000924974,0.004073538,0.000005814972,0.0004479926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00410343,"threshold_uncertainty_score":0.01357645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04332455212688859,"score_gpt":0.2955784045651831,"score_spread":0.2522538524382946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}