{"id":"W2981870649","doi":"10.1371/journal.pbio.3000379","title":"Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence","year":2019,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Motility; Flagellum; Microbiology; Virulence; Pilus; Signal transduction; Population; Phenotype; Phase variation; Response regulator; Cell biology; Bacteria; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699861,0.0003428279,0.0001634145,0.0002223347,0.0000956775,0.0002673936,0.0001556346,0.0002298718,0.0004283687],"category_scores_gemma":[0.0002700808,0.0001309504,0.000152668,0.0001156809,0.0001882953,0.0001491257,0.0001951227,0.0003471187,0.000145466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003828694,"about_ca_system_score_gemma":0.0001854574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003785125,"about_ca_topic_score_gemma":0.0004434689,"domain_scores_codex":[0.9998159,0.00003935261,0.00001308914,0.0000339724,0.0000493734,0.00004836794],"domain_scores_gemma":[0.9997506,0.00005462446,0.0001010004,0.00002432412,0.00002930559,0.00004025927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004379308,0.00001265832,0.000209488,0.000004898322,8.114039e-7,0.00000843558,0.000003617484,0.00003249067,0.9992107,0.00001805075,0.000005137825,0.0004498399],"study_design_scores_gemma":[0.00002677694,0.0004794847,0.02754705,0.000004459301,0.00001038774,0.0002082277,0.00004878362,0.004130824,0.9669657,0.00007202227,0.0004910628,0.00001528433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963478,0.0002843464,0.00285458,0.00004011524,0.000008041992,0.00002276965,0.00006975011,0.00004871795,0.0003237709],"genre_scores_gemma":[0.9976412,0.0001450531,0.001745272,0.00002482276,0.000005673265,0.00002248552,0.0001203074,0.00001035615,0.0002847459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004283687,"threshold_uncertainty_score":0.002777934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02432053589787999,"score_gpt":0.2961816878219152,"score_spread":0.2718611519240353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}