{"id":"W2981903391","doi":"10.3389/fpsyt.2019.00808","title":"Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma","year":2019,"lang":"en","type":"review","venue":"Frontiers in Psychiatry","topic":"Birth, Development, and Health","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Epigenetics; Anxiety; Phenotype; Disease; Psychology; Mental health; DNA methylation; Clinical psychology; Traumatic stress; Medicine; Psychiatry; Bioinformatics; Gene; Genetics; Biology; Internal medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006950789,0.0005261216,0.002185131,0.001143611,0.00007754763,0.00002156786,0.0003212893,0.0007088936,0.00002564099],"category_scores_gemma":[0.00007880252,0.0004349908,0.000235648,0.001176932,0.00008009957,0.0000469642,0.00002696994,0.001054169,0.00003409811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006531606,"about_ca_system_score_gemma":0.00415936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002589853,"about_ca_topic_score_gemma":0.0004068202,"domain_scores_codex":[0.9966933,0.0005119432,0.0010576,0.0007506289,0.0003646903,0.0006218658],"domain_scores_gemma":[0.9983991,0.00008337892,0.0004964384,0.0007671922,0.00005341593,0.000200487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0005988164,0.002556589,0.1746324,0.01900423,0.0008807189,0.00004398992,0.001227692,0.00001224384,7.111803e-8,0.0006365217,0.02947433,0.7709324],"study_design_scores_gemma":[0.007052114,0.0007853743,0.5824245,0.09747463,0.001711924,0.00006945516,0.001118794,0.00003904437,5.001235e-7,0.001705034,0.3060393,0.00157932],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001572837,0.9898053,0.0001522834,0.0004417979,0.004330324,0.002443299,0.0001307514,0.00005876425,0.001064597],"genre_scores_gemma":[0.0001960436,0.9886308,0.009659072,0.0002010871,0.0001771697,0.0002615922,0.0004606264,0.000123289,0.0002903342],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7693532,"threshold_uncertainty_score":0.9998102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03592906217020575,"score_gpt":0.3229290527473813,"score_spread":0.2869999905771756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}