{"id":"W2981905539","doi":"10.1097/aln.0000000000002992","title":"Sevoflurane Promotes Bactericidal Properties of Macrophages through Enhanced Inducible Nitric Oxide Synthase Expression in Male Mice","year":2019,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Society of Nephrology","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Sevoflurane; Lipopolysaccharide; Proinflammatory cytokine; Nitric oxide synthase; In vivo; Tumor necrosis factor alpha; Medicine; Macrophage; Phagocytosis; Pharmacology; Immunology; Inflammation; Molecular biology; Microbiology; In vitro; Biology; Nitric oxide; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005293147,0.0008918453,0.0005565218,0.0008118608,0.0002421834,0.0004221204,0.000368831,0.0007204696,0.001877052],"category_scores_gemma":[0.0001991197,0.0004275271,0.0006939807,0.0001957872,0.0004724095,0.0004714552,0.0002937585,0.001276696,0.0006925321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002656258,"about_ca_system_score_gemma":0.0003281522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002247689,"about_ca_topic_score_gemma":0.0004186356,"domain_scores_codex":[0.9995744,0.00007257223,0.00003883875,0.00008883481,0.00009972376,0.0001256009],"domain_scores_gemma":[0.9995806,0.00002588468,0.0001824775,0.00003856891,0.00004548474,0.0001270309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001363526,0.0003387214,0.0005298138,0.00006580896,0.00001075114,0.0001115845,0.00004026083,0.00003559175,0.9957833,0.00008617884,0.00009211368,0.001542256],"study_design_scores_gemma":[0.000504719,0.01088118,0.02075303,0.0000606319,0.0001137698,0.0008221022,0.000184912,0.0008608995,0.9614376,0.0002256939,0.004116998,0.00003836615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929885,0.001923651,0.002726708,0.0004315167,0.0001156934,0.00007833885,0.0006071515,0.0001994975,0.0009289804],"genre_scores_gemma":[0.9867776,0.002251316,0.003411534,0.0004092888,0.00009915866,0.0003167994,0.001013783,0.00007953258,0.005640948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001877052,"threshold_uncertainty_score":0.006279349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121416672068098,"score_gpt":0.2179969444375515,"score_spread":0.2058552772307417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}