{"id":"W2981939799","doi":"10.1016/j.jtho.2019.08.473","title":"OA12.03 Initial Reporting of NRG-LU001, Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; University of Texas MD Anderson Cancer Center; Universität des Saarlandes; Johannes Gutenberg-Universität Mainz; NRG Oncology; Thomas Jefferson University; Erasmus+; Albert-Ludwigs-Universität Freiburg; Hamilton Health Sciences","keywords":"Medicine; Internal medicine; Carboplatin; Clinical endpoint; Metformin; Chemoradiotherapy; Oncology; Regimen; Randomized controlled trial; Progression-free survival; Response Evaluation Criteria in Solid Tumors; Lung cancer; Cumulative incidence; Hazard ratio; Phases of clinical research; Chemotherapy; Confidence interval; Cohort; Cisplatin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004080036,0.001352915,0.003036124,0.0004635427,0.0005161832,0.002258883,0.001160428,0.001800438,0.01025399],"category_scores_gemma":[0.00493922,0.0006925876,0.002793821,0.0006416096,0.000939857,0.001092359,0.0005043237,0.004129826,0.002508537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001562279,"about_ca_system_score_gemma":0.002527039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002858557,"about_ca_topic_score_gemma":0.009343578,"domain_scores_codex":[0.9984464,0.0008627624,0.0001443434,0.0002448972,0.0001403394,0.0001612297],"domain_scores_gemma":[0.9975119,0.0007621912,0.0004296173,0.0002796828,0.0003182602,0.0006984668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.899978,0.002608876,0.001950259,0.001778696,0.004176319,0.0001070666,0.00009600931,0.0005387661,0.007745912,0.0003901593,0.01171018,0.06891979],"study_design_scores_gemma":[0.9457075,0.04084167,0.004624975,0.0001554881,0.00199853,0.00005592347,0.00002799988,0.0003873146,0.0008524875,0.0002307823,0.005087837,0.00002945383],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8899499,0.02367659,0.003491975,0.01542633,0.005525312,0.01393994,0.01852711,0.001697377,0.02776551],"genre_scores_gemma":[0.9458786,0.006111869,0.004468922,0.009015837,0.001932895,0.005562394,0.009395909,0.0002388283,0.01739476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01025399,"threshold_uncertainty_score":0.03430301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03828137303503014,"score_gpt":0.4626978119202523,"score_spread":0.4244164388852221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}