{"id":"W2981939799","doi":"10.1016/j.jtho.2019.08.473","title":"OA12.03 Initial Reporting of NRG-LU001, Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; University of Texas MD Anderson Cancer Center; Universität des Saarlandes; Johannes Gutenberg-Universität Mainz; NRG Oncology; Thomas Jefferson University; Erasmus+; Albert-Ludwigs-Universität Freiburg; Hamilton Health Sciences","keywords":"Medicine; Internal medicine; Carboplatin; Clinical endpoint; Metformin; Chemoradiotherapy; Oncology; Regimen; Randomized controlled trial; Progression-free survival; Response Evaluation Criteria in Solid Tumors; Lung cancer; Cumulative incidence; Hazard ratio; Phases of clinical research; Chemotherapy; Confidence interval; Cohort; Cisplatin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005417821,0.000196876,0.003286552,0.0005536602,0.00001961311,0.000004920581,0.000189243,0.0001574271,0.000397363],"category_scores_gemma":[0.001962995,0.0001457092,0.0006344492,0.0003500961,0.0001577615,0.0001660686,0.00005050485,0.0004509977,0.000001880646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873291,"about_ca_system_score_gemma":0.0007760189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002091669,"about_ca_topic_score_gemma":0.000009463543,"domain_scores_codex":[0.9946447,0.0002906829,0.00409478,0.0001827446,0.0005143851,0.0002727078],"domain_scores_gemma":[0.991146,0.0005526778,0.007578498,0.0002329501,0.0003755126,0.0001143838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6033779,0.00140092,0.0004480066,0.0002176825,0.0003490687,0.0002613206,0.0005273126,0.00004315,0.005036232,0.00004178228,0.0002253413,0.3880712],"study_design_scores_gemma":[0.9614056,0.01650779,0.0002218543,0.0005770291,0.0007210333,0.0003585043,0.0006268211,0.0003565485,0.01119709,0.0001222295,0.007752422,0.0001530432],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897404,0.0009470269,0.001001872,0.001202144,0.002217248,0.00142647,0.000002544029,0.000007601815,0.003454684],"genre_scores_gemma":[0.9950075,0.000414002,0.00343951,0.0002316027,0.0004298435,0.0000138583,0.000004983834,0.00002023453,0.0004384258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3879182,"threshold_uncertainty_score":0.5941851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03828137303503014,"score_gpt":0.4626978119202523,"score_spread":0.4244164388852221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}