{"id":"W2981956000","doi":"10.2147/dddt.s215895","title":"<p>Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity</p>","year":2019,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"National Natural Science Foundation of China","keywords":"Podophyllotoxin; Etoposide; Cytotoxicity; Chemistry; Stereochemistry; Cell culture; Glucoside; Acetylation; In vitro; Pharmacology; Biochemistry; Biology; Chemotherapy; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001058956,0.0002757327,0.0001121028,0.0001549757,0.0001002715,0.0001486945,0.0001510331,0.0001479727,0.001218594],"category_scores_gemma":[0.0001217131,0.00007572785,0.0001428715,0.0002871398,0.0001414546,0.0002542468,0.0001329775,0.0003572623,0.0004911174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00015094,"about_ca_system_score_gemma":0.0001659836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002898415,"about_ca_topic_score_gemma":0.0003178929,"domain_scores_codex":[0.9999461,0.00000884761,0.000007013375,0.000009557483,0.00001859633,0.000009790162],"domain_scores_gemma":[0.9999262,0.000007290649,0.00002663413,0.0000113684,0.00001262246,0.00001591167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008380514,0.00004818283,0.0002758291,0.00009597262,0.000005132777,0.0001628699,0.00001541726,0.0003662665,0.9870123,0.000264378,0.0001303127,0.0115395],"study_design_scores_gemma":[0.00001802773,0.0007318967,0.002178932,0.00001091319,0.00001485582,0.0003686298,0.00001179155,0.000591909,0.990229,0.0001047913,0.005732607,0.000006555504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679013,0.003947481,0.01581445,0.0002679361,0.00005138219,0.0001628486,0.001175857,0.0001881183,0.01049064],"genre_scores_gemma":[0.9791303,0.002819021,0.01234066,0.0001095997,0.00001777319,0.00008256425,0.001193474,0.00005905572,0.004247598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218594,"threshold_uncertainty_score":0.0040766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059583938527535,"score_gpt":0.2040505863657764,"score_spread":0.183454746980501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}