{"id":"W2981956000","doi":"10.2147/dddt.s215895","title":"<p>Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity</p>","year":2019,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"National Natural Science Foundation of China","keywords":"Podophyllotoxin; Etoposide; Cytotoxicity; Chemistry; Stereochemistry; Cell culture; Glucoside; Acetylation; In vitro; Pharmacology; Biochemistry; Biology; Chemotherapy; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000328052,0.0003063328,0.0003801476,0.00005796856,0.00009788657,0.00003707689,0.0001733226,0.0001419998,0.00001668604],"category_scores_gemma":[0.0000281699,0.0002357449,0.00006054757,0.00007823003,0.0001601069,0.00001692381,0.00009250261,0.00006931469,0.000004747782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001304869,"about_ca_system_score_gemma":0.0001303598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002947641,"about_ca_topic_score_gemma":0.000002817824,"domain_scores_codex":[0.9986079,0.0001445143,0.0002804585,0.0004820246,0.0001923086,0.0002927704],"domain_scores_gemma":[0.9993955,0.00008297725,0.0001434195,0.0002296528,0.00005535264,0.00009309508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004369662,0.0001559888,0.00136243,0.00004714325,0.0001749897,0.000001466491,0.000341926,0.000001056943,0.9839662,0.00005203506,0.0001394688,0.01332029],"study_design_scores_gemma":[0.0005326216,0.0001038525,0.00482348,0.00008470938,0.000009362661,0.000009260929,0.00004842646,0.0000265279,0.9856559,0.0000402687,0.008306506,0.0003590919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946688,0.003966181,0.0004705327,0.00007369825,0.0000353194,0.0004683656,0.00001135886,0.00001752789,0.0002882346],"genre_scores_gemma":[0.9938168,0.00251701,0.003133909,0.0001046331,0.00005211503,0.00006502029,0.00001996356,0.00002963319,0.000260928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0129612,"threshold_uncertainty_score":0.96134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059583938527535,"score_gpt":0.2040505863657764,"score_spread":0.183454746980501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}