{"id":"W2982004779","doi":"10.1002/stem.3106","title":"Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells","year":2019,"lang":"en","type":"article","venue":"Stem Cells","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; National Heart, Lung, and Blood Institute; Heart Rhythm Society; American Heart Association","keywords":"Wnt signaling pathway; Biology; Embryonic stem cell; Cell biology; Myocyte; Cellular differentiation; Cardiac pacemaker; Stem cell; Sinoatrial node; Beta-catenin; Pacemaker potential; Induced pluripotent stem cell; NODAL; Signal transduction; Internal medicine; Endocrinology; Anatomy; Neuroscience; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001042612,0.000206378,0.0001222144,0.0001882404,0.0000799428,0.0001977836,0.00006547419,0.0001122474,0.001021426],"category_scores_gemma":[0.00009035558,0.000153392,0.0001934731,0.0001147422,0.00008502499,0.0001011198,0.0001811683,0.0002245122,0.0002839545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001434343,"about_ca_system_score_gemma":0.0001740061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006294477,"about_ca_topic_score_gemma":0.001310983,"domain_scores_codex":[0.9999012,0.00001409389,0.00001439831,0.00002062606,0.0000309121,0.00001875899],"domain_scores_gemma":[0.9999528,0.000008273616,0.0000112864,0.000004868913,0.000005733563,0.0000170554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002868257,0.000004008246,0.0002181716,0.00001533989,0.00000163417,0.00003291619,0.00001335951,0.0000169655,0.99902,0.00007991281,0.00001335787,0.0005556876],"study_design_scores_gemma":[0.00001078984,0.00009675678,0.01037696,0.000009849718,0.00001398966,0.0002519724,0.00002373756,0.0006190963,0.9844391,0.00004503386,0.004109878,0.000002849342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923779,0.001712541,0.002550249,0.00004296448,0.00001577396,0.00003062348,0.0004388544,0.00004615689,0.002785076],"genre_scores_gemma":[0.9894739,0.001363309,0.002916408,0.00003827311,0.000005780083,0.00003877489,0.0008626932,0.00002559991,0.005275286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021426,"threshold_uncertainty_score":0.003416955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425686810661492,"score_gpt":0.2440696950310197,"score_spread":0.2298128269244047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}