{"id":"W2982004779","doi":"10.1002/stem.3106","title":"Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells","year":2019,"lang":"en","type":"article","venue":"Stem Cells","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; National Heart, Lung, and Blood Institute; Heart Rhythm Society; American Heart Association","keywords":"Wnt signaling pathway; Biology; Embryonic stem cell; Cell biology; Myocyte; Cellular differentiation; Cardiac pacemaker; Stem cell; Sinoatrial node; Beta-catenin; Pacemaker potential; Induced pluripotent stem cell; NODAL; Signal transduction; Internal medicine; Endocrinology; Anatomy; Neuroscience; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003651765,0.0002707913,0.0004025567,0.0000720887,0.00007966152,0.00005565521,0.0001787078,0.0002860516,0.00007801777],"category_scores_gemma":[0.000001687903,0.0002670923,0.0001758493,0.0001025336,0.0001181613,0.00001008756,0.0002701402,0.0002167532,0.0001035847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004254318,"about_ca_system_score_gemma":0.0001469473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001284542,"about_ca_topic_score_gemma":0.00003988265,"domain_scores_codex":[0.9978602,0.0002278452,0.0003983373,0.0006872677,0.0003534224,0.0004729532],"domain_scores_gemma":[0.9987972,0.000099754,0.0001537076,0.0005884166,0.0001605717,0.0002003067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007725002,0.00008352131,0.000947801,0.0001823642,0.0000718489,0.000004993515,0.000198821,0.00001624395,0.9976631,0.000004302806,0.0001433611,0.0006064065],"study_design_scores_gemma":[0.0005080443,0.0003420181,0.0004138749,0.00002805303,0.00003756751,0.000001305029,0.0003061456,0.00006176507,0.9961395,0.000003557342,0.001870977,0.0002872051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962113,0.001858398,0.00004422198,0.00001356674,0.0001905958,0.0009211685,0.0001199414,0.000016484,0.0006242608],"genre_scores_gemma":[0.9929249,0.0001362091,0.0001385228,0.000016311,0.0001312459,0.0000155893,0.00004979516,0.00005869746,0.006528711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00590445,"threshold_uncertainty_score":0.9999781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425686810661492,"score_gpt":0.2440696950310197,"score_spread":0.2298128269244047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}