{"id":"W2982006614","doi":"10.1158/0008-5472.can-19-0729","title":"A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells","year":2019,"lang":"en","type":"letter","venue":"Cancer Research","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Cancer cell; Cancer; Acquired resistance; Kinase; Cancer research; Biology; Receptor tyrosine kinase; Drug resistance; Cell culture; Tyrosine kinase; Signal transduction; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001209759,0.0004880332,0.0006759618,0.0008108399,0.0001227941,0.00008352892,0.0006423534,0.001230787,0.0003283739],"category_scores_gemma":[0.0003638583,0.0005179126,0.0001937576,0.001399519,0.0002489139,0.00001797822,0.0006253373,0.001266464,0.0001479907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001378134,"about_ca_system_score_gemma":0.001325222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001675184,"about_ca_topic_score_gemma":0.002933588,"domain_scores_codex":[0.993835,0.0008843506,0.0007004252,0.001510251,0.001615708,0.001454291],"domain_scores_gemma":[0.9972919,0.0001572337,0.0002535715,0.001005729,0.00110993,0.0001816882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007245105,0.00006445304,0.0001125327,0.0009222364,0.00005612709,0.0000457001,0.00002277147,0.00002373885,0.6501782,0.000008975499,0.3476876,0.0001531903],"study_design_scores_gemma":[0.0009390617,0.0006851919,0.0002843103,0.001179062,0.00001336513,0.000002453507,0.00001548027,0.000008652702,0.8728096,0.0001366463,0.1234689,0.0004573508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9512756,0.001357068,0.0004168883,0.04122167,0.0005583313,0.003204878,0.001673517,0.00002948354,0.0002625535],"genre_scores_gemma":[0.9543136,0.0005430444,0.001345979,0.01567227,0.003313231,0.002620258,0.001277415,0.0003970736,0.02051709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2242187,"threshold_uncertainty_score":0.9997272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04447817416959338,"score_gpt":0.3423194134676556,"score_spread":0.2978412392980622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}