{"id":"W2982022472","doi":"10.1139/cjpp-2019-0383","title":"The pharmacokinetics of mycophenolic acid in rats with orotic acid induced nonalcoholic fatty liver disease","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Foundation of Korea; Catholic University of Korea; Ministry of Science, ICT and Future Planning; National Research Foundation","keywords":"Nonalcoholic fatty liver disease; Pharmacokinetics; Mycophenolic acid; Internal medicine; Glucuronidation; Orotic acid; Endocrinology; Metabolite; Oral administration; Liver disease; Mycophenolate; Medicine; Excretion; Pharmacology; Transplantation; Chemistry; Fatty liver; Enzyme; Microsome; Biochemistry; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266426,0.0004863912,0.0007732961,0.0005394891,0.0002384421,0.0003289008,0.0001642057,0.0004686612,0.0009498043],"category_scores_gemma":[0.0003063821,0.000257376,0.000353899,0.0003668946,0.0003817282,0.0004906207,0.0002112965,0.001083495,0.0002386293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004334678,"about_ca_system_score_gemma":0.0005326937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001372511,"about_ca_topic_score_gemma":0.001816858,"domain_scores_codex":[0.9997949,0.00003442042,0.00001606314,0.00004095346,0.00005687788,0.00005682789],"domain_scores_gemma":[0.9996388,0.00002699079,0.0001198634,0.0000364557,0.00004613014,0.0001316977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01409932,0.001354209,0.007301825,0.000101481,0.00006342798,0.0003151918,0.0001556201,0.0001972471,0.9660055,0.0001303888,0.0001524187,0.01012332],"study_design_scores_gemma":[0.0006296377,0.03179558,0.08798639,0.00002176357,0.000326544,0.001073571,0.0003841688,0.004059782,0.8697445,0.0002771343,0.003610721,0.0000902258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978027,0.0006854896,0.0007908012,0.00006717328,0.00003486603,0.0000303545,0.0001556502,0.00004846216,0.0003845039],"genre_scores_gemma":[0.9949887,0.0009471349,0.00146427,0.0001124594,0.00002133987,0.00007986621,0.0003574282,0.00002529925,0.002003496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372511,"threshold_uncertainty_score":0.003177404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916041604228562,"score_gpt":0.2863427493661876,"score_spread":0.267182333323902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}