{"id":"W2982050900","doi":"","title":"Predictable patterns of CTL escape and reversion and the limited role of epistasis in HIV-1 evolution","year":2015,"lang":"en","type":"article","venue":"arXiv (Cornell University)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Reversion; CTL*; Biology; Population; Genetics; Genetic Fitness; Epistasis; Mutation; Point mutation; Viral evolution; Host (biology); Mutation rate; Virus; Virology; Evolutionary biology; Cytotoxic T cell; Phenotype; Biological evolution; RNA; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001150468,0.0002184711,0.0003565086,0.0007142516,0.0004234996,0.0005275616,0.0002972437,0.0003091797,0.000942898],"category_scores_gemma":[0.003599094,0.0002112038,0.0003235447,0.0003700189,0.0005877693,0.0003476528,0.0006061208,0.0003474609,0.0001127945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004302163,"about_ca_system_score_gemma":0.0003358295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002845251,"about_ca_topic_score_gemma":0.007066398,"domain_scores_codex":[0.9992886,0.0002690093,0.000043499,0.0002285117,0.0001056321,0.00006471487],"domain_scores_gemma":[0.9980289,0.0009129209,0.0004752324,0.0003759505,0.0001227915,0.00008421462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005332573,0.0001270928,0.5984957,0.0001567256,0.0006231634,0.0003254568,0.0009543538,0.0116565,0.3520706,0.001707606,0.0001969103,0.0331527],"study_design_scores_gemma":[0.0000106912,0.0001870342,0.9757121,0.000005341447,0.00007106251,0.0003166436,0.0002601963,0.01660161,0.005114816,0.001329608,0.0003613686,0.00002949089],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997341,0.00008456197,0.002144955,0.00001934719,9.959331e-7,0.000007214378,0.00007190266,0.00002378216,0.0003063024],"genre_scores_gemma":[0.9991196,0.00002961441,0.0006972161,0.000008312923,0.000001040073,0.00000771441,0.00007462505,0.000006891741,0.00005496842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002845251,"threshold_uncertainty_score":0.006084383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02793673666598566,"score_gpt":0.1678467624785961,"score_spread":0.1399100258126104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}