{"id":"W2982150916","doi":"10.1021/acs.inorgchem.9b02350","title":"Evaluation of the Tetrakis(3-Hydroxy-4-Pyridinone) Ligand THPN with Zirconium(IV): Thermodynamic Solution Studies, Bifunctionalization, and in Vivo Assessment of Macromolecular <sup>89</sup>Zr-THPN-Conjugates","year":2019,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF; BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Lundbeckfonden","keywords":"Chemistry; Bifunctional; Chelation; In vivo; Conjugate; Ligand (biochemistry); Chemical stability; Titration; Zirconium; In vitro; Nuclear chemistry; Combinatorial chemistry; Biochemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002133818,0.0002978335,0.0001712734,0.00007865353,0.00007468239,0.0001292848,0.0001863583,0.0002009921,0.0004309427],"category_scores_gemma":[0.0002300845,0.00009032241,0.0000957579,0.00008791408,0.0001765551,0.0001522972,0.0001618676,0.0002291459,0.0001351441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003546914,"about_ca_system_score_gemma":0.0001439197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007853385,"about_ca_topic_score_gemma":0.0009245727,"domain_scores_codex":[0.9998997,0.00002580642,0.000005674506,0.00002592416,0.00002859274,0.00001414752],"domain_scores_gemma":[0.9999113,0.00001926467,0.00003447266,0.00000486826,0.0000155596,0.00001445151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008161712,0.000009941313,0.00006495044,0.00003316398,0.00000333819,0.00001011374,0.00001137537,0.0001608261,0.998358,0.00003271103,0.0000127608,0.001221179],"study_design_scores_gemma":[0.000004524238,0.0002841152,0.0003355482,0.000001614309,0.000006208163,0.00004026453,0.000005270437,0.0006492466,0.9980235,0.000005537759,0.0006417255,0.000002574604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926822,0.001311963,0.005278144,0.0000296686,0.000009446865,0.00003277791,0.00008527107,0.00003689167,0.0005337158],"genre_scores_gemma":[0.9929904,0.0006850799,0.005025273,0.00002074445,0.000005126743,0.00003108743,0.0001255506,0.0000175916,0.001099216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007853385,"threshold_uncertainty_score":0.00257349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895076946643105,"score_gpt":0.3056066804239659,"score_spread":0.2866559109575349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}