{"id":"W2982150916","doi":"10.1021/acs.inorgchem.9b02350","title":"Evaluation of the Tetrakis(3-Hydroxy-4-Pyridinone) Ligand THPN with Zirconium(IV): Thermodynamic Solution Studies, Bifunctionalization, and in Vivo Assessment of Macromolecular <sup>89</sup>Zr-THPN-Conjugates","year":2019,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF; BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Lundbeckfonden","keywords":"Chemistry; Bifunctional; Chelation; In vivo; Conjugate; Ligand (biochemistry); Chemical stability; Titration; Zirconium; In vitro; Nuclear chemistry; Combinatorial chemistry; Biochemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005207131,0.0001863457,0.0003177596,0.00002539306,0.0000588748,0.000009053451,0.0001239847,0.00012513,0.0002842819],"category_scores_gemma":[0.0001001606,0.0001382472,0.00005786668,0.0003907285,0.0002208967,0.00006148151,0.0000617883,0.0002279208,0.000001351651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002836123,"about_ca_system_score_gemma":0.0004055001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001433791,"about_ca_topic_score_gemma":0.000002981896,"domain_scores_codex":[0.9983716,0.0000480023,0.0004051799,0.0003383154,0.0006645249,0.0001723491],"domain_scores_gemma":[0.9987766,0.00008477824,0.000215237,0.0004241929,0.0004358687,0.00006334222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004433721,0.0002011267,0.02001909,0.000515632,0.0002035059,0.000001010826,0.0001460641,0.0009082676,0.9777988,0.00004822711,0.00002799568,0.00008597492],"study_design_scores_gemma":[0.002402775,0.00003906035,0.01158701,0.0003043268,0.0004748428,0.00006953773,0.0003740632,0.04380679,0.9404981,0.0002413581,0.0000608047,0.0001413894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956969,0.001073413,0.0001110259,0.0004603383,0.00002211288,0.000600774,0.00002642727,0.0000171954,0.001991832],"genre_scores_gemma":[0.9993602,0.0001503581,0.00006356146,0.00005825754,0.00004298881,0.00004940721,0.00003490797,0.00002129826,0.000219028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04289852,"threshold_uncertainty_score":0.5637558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895076946643105,"score_gpt":0.3056066804239659,"score_spread":0.2866559109575349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}