{"id":"W2982162177","doi":"10.1093/molbev/msz249","title":"HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation","year":2019,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Frederick National Laboratory for Cancer Research; Deutsche Forschungsgemeinschaft; Center for Cancer Research","keywords":"Heterozygote advantage; Biology; Human leukocyte antigen; Allele; Loss of heterozygosity; Balancing selection; Compound heterozygosity; Genetics; HLA-B Antigens; HLA-A; Immunology; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003048399,0.0001601581,0.0002732067,0.000529376,0.0002150306,0.0004812722,0.0001131453,0.0002312818,0.001780122],"category_scores_gemma":[0.0006827969,0.0001137055,0.0001685447,0.0003850187,0.0002380457,0.0001773422,0.000307093,0.0002421019,0.0001614716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005824492,"about_ca_system_score_gemma":0.00006291457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002436295,"about_ca_topic_score_gemma":0.0002533976,"domain_scores_codex":[0.9996557,0.00007273085,0.00003861572,0.0001072593,0.00007181746,0.00005381722],"domain_scores_gemma":[0.9996676,0.00007742591,0.0001340203,0.00003626029,0.00002161685,0.00006302015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009297376,0.00006855121,0.2559724,0.0000953121,0.0001352172,0.0009518642,0.0002440262,0.0002269406,0.7294242,0.0002963458,0.0001612044,0.01149428],"study_design_scores_gemma":[0.00001486221,0.0004272449,0.9627251,0.00001305201,0.00006359899,0.006442721,0.0003143933,0.0007681056,0.0280027,0.0004609016,0.0007489544,0.00001847401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991774,0.000166509,0.0002929685,0.00001160074,0.000002296549,0.000002047392,0.000132292,0.00000365903,0.0002113401],"genre_scores_gemma":[0.9995514,0.00006097735,0.000169058,0.0000124879,0.000003771062,0.000002022008,0.0001220532,0.000002440069,0.00007579041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780122,"threshold_uncertainty_score":0.0059551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275185122817724,"score_gpt":0.2767519565648465,"score_spread":0.2640001053366693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}