{"id":"W2982170820","doi":"10.1016/j.jns.2019.116505","title":"Change in visual acuity and retinal structures following Repository Corticotropin Injection (RCI) therapy in patients with acute demyelinating optic neuritis: Improvement in low contrast visual acuity in both affected and contralateral eyes in a single-armed open-label study","year":2019,"lang":"en","type":"article","venue":"Journal of the Neurological Sciences","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Mallinckrodt Pharmaceuticals; Edward Mallinckrodt, Jr. Foundation","keywords":"Optic neuritis; Visual acuity; Medicine; Contrast (vision); Ophthalmology; Retinal; Multiple sclerosis; Neuro-ophthalmology; Glaucoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002107551,0.001647955,0.002931778,0.0006499029,0.0006394312,0.0009222571,0.0007631883,0.001692228,0.001447813],"category_scores_gemma":[0.00209748,0.0005983924,0.001529528,0.0007737844,0.001610242,0.001349856,0.0003441677,0.001975391,0.0003969343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008433673,"about_ca_system_score_gemma":0.0007892791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00178191,"about_ca_topic_score_gemma":0.001904226,"domain_scores_codex":[0.9988662,0.000509451,0.0001173632,0.0001891704,0.0001536543,0.0001641711],"domain_scores_gemma":[0.9977558,0.0007299952,0.0005800256,0.0002170051,0.0001285795,0.0005885565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.846853,0.03708456,0.06959166,0.0005931002,0.001665338,0.0005445564,0.000408828,0.0005449465,0.0151652,0.00006847044,0.0003492865,0.02713108],"study_design_scores_gemma":[0.1829023,0.5096302,0.2988724,0.00005183521,0.001634946,0.0006812523,0.0002804555,0.001631243,0.003280731,0.0001301026,0.0007674602,0.0001369668],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990547,0.0004476767,0.00005444939,0.00002594668,0.0000189474,0.0001217713,0.00007746431,0.000005836924,0.0001931363],"genre_scores_gemma":[0.9988022,0.0002891158,0.0001312022,0.00008555631,0.00009199131,0.0001349124,0.0002303294,0.000002919028,0.0002318151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002931778,"threshold_uncertainty_score":0.01114589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03762574910848878,"score_gpt":0.3423759178369002,"score_spread":0.3047501687284114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}