{"id":"W2982299779","doi":"10.1101/820845","title":"Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; Bayer HealthCare; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Medical Research Council; Ministero dello Sviluppo Economico; Kennedy Trust for Rheumatology Research; National Institute for Health and Care Research; Genome Canada; Fondation Leducq; Pfizer; Eli Lilly and Company","keywords":"Effector; Demethylase; Biology; Transcription factor; Cell biology; Chromatin; Histone; Reprogramming; Cytokine; Cell growth; Cell; Immunology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394646,0.000233354,0.0002010195,0.000230889,0.0001142618,0.0003099872,0.0001262471,0.0002144591,0.002566883],"category_scores_gemma":[0.0001135672,0.0001425111,0.0001810569,0.0001955093,0.0001602296,0.0001079034,0.0001766909,0.0003267154,0.001387252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002098611,"about_ca_system_score_gemma":0.0002038607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000566695,"about_ca_topic_score_gemma":0.0007520707,"domain_scores_codex":[0.9999286,0.000007449636,0.000003061929,0.00001741065,0.0000241637,0.00001928117],"domain_scores_gemma":[0.9999654,0.000005008641,0.000008374738,0.000007522216,0.000005792007,0.000007829301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003343819,0.00001479283,0.001166895,0.00006733298,0.00001190288,0.00009044301,0.00001962962,0.0002786223,0.9904731,0.0002402163,0.0005410114,0.006761677],"study_design_scores_gemma":[0.00002556956,0.00006685723,0.0115203,0.000007618994,0.00001510877,0.000211095,0.00002715979,0.001203845,0.9783549,0.0002294377,0.008333724,0.000004353801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9574491,0.01283198,0.01308292,0.0007200977,0.0002143209,0.00004736697,0.003344342,0.0007397664,0.01157006],"genre_scores_gemma":[0.9752922,0.004938664,0.004238318,0.0001201132,0.00004876634,0.00002942708,0.00251242,0.0001181155,0.01270207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002566883,"threshold_uncertainty_score":0.008587062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132411668235156,"score_gpt":0.2178742524024657,"score_spread":0.2065501357201141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}