{"id":"W2982303852","doi":"10.12688/f1000research.20013.1","title":"Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment","year":2019,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Medulloblastoma; Open peer review; Plant biology; Suppressor; Tumor microenvironment; Neuroscience; Biology; Medicine; Cancer research; Tumor cells; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007584897,0.0005884119,0.0005973382,0.001178469,0.0001833356,0.0009639072,0.000324059,0.0008296766,0.001253193],"category_scores_gemma":[0.0004364265,0.0002106901,0.0003201722,0.001143962,0.0005436637,0.001437107,0.0005572758,0.001155529,0.0007443095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007102147,"about_ca_system_score_gemma":0.0005919825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005490946,"about_ca_topic_score_gemma":0.000651186,"domain_scores_codex":[0.999854,0.00002209876,0.0000204278,0.00003795574,0.00004298677,0.00002257299],"domain_scores_gemma":[0.9997677,0.00007446623,0.00003656065,0.00001289189,0.00007168946,0.0000365565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007341136,0.0001148859,0.001599938,0.01472943,0.0001532336,0.001210632,0.0004939951,0.001033273,0.1357129,0.01543526,0.01647035,0.8123121],"study_design_scores_gemma":[0.00004779967,0.0005333733,0.009292815,0.001378492,0.0003157338,0.003719775,0.0004792392,0.0007168115,0.06908537,0.01688168,0.8974783,0.00007050799],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005015895,0.9878726,0.001881352,0.001936903,0.0003672716,0.000007342298,0.00008074999,0.00004738426,0.00279054],"genre_scores_gemma":[0.01764794,0.977484,0.001866345,0.0004473406,0.0007822377,0.00001063017,0.000192021,0.00001381747,0.001555609],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001253193,"threshold_uncertainty_score":0.005153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01649515319693987,"score_gpt":0.3065123761537874,"score_spread":0.2900172229568475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}