{"id":"W2982324039","doi":"10.7150/thno.35280","title":"Nanotopography-based lymphatic delivery for improved anti-tumor responses to checkpoint blockade immunotherapy","year":2019,"lang":"en","type":"article","venue":"Theranostics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kimberly-Clark (Canada)","funders":"Kimberly-Clark; Cancer Prevention and Research Institute of Texas","keywords":"Medicine; Lymphatic system; Immunotherapy; Immune checkpoint; Cancer research; Immune system; Cancer immunotherapy; Pharmacology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005278812,0.0001897028,0.0001055711,0.0001372765,0.00005082639,0.0001540511,0.0001207248,0.0002278181,0.0006831546],"category_scores_gemma":[0.00009230892,0.00004714113,0.00009547908,0.00007993617,0.0001276319,0.0001513507,0.0001462033,0.0001841619,0.0001990292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002014827,"about_ca_system_score_gemma":0.0001068013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002065042,"about_ca_topic_score_gemma":0.0003496705,"domain_scores_codex":[0.9999607,0.000004319934,0.00000244594,0.00001158322,0.00001419748,0.000006686501],"domain_scores_gemma":[0.9999636,0.000008112641,0.00001562797,0.000002944703,0.000004991974,0.000004714764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003131815,0.00001708733,0.0001292789,0.00005017558,0.000001881664,0.00002076362,0.000005808167,0.0004626058,0.993006,0.00009041619,0.00006474763,0.006119815],"study_design_scores_gemma":[0.00001361075,0.0003211744,0.001296026,0.000005637835,0.00001222592,0.0001365555,0.000006913873,0.00509668,0.990035,0.0000485133,0.003022949,0.000004730575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9283584,0.00548763,0.06088913,0.0003863815,0.00009309701,0.0001334945,0.0002431915,0.00041655,0.003992071],"genre_scores_gemma":[0.9821619,0.001272352,0.01392923,0.0001422167,0.00002701318,0.00006147829,0.00007395886,0.00001995364,0.002311776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006831546,"threshold_uncertainty_score":0.002285421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009880067014919083,"score_gpt":0.2405152315056859,"score_spread":0.2306351644907668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}