{"id":"W2982325216","doi":"10.1016/j.isci.2019.10.054","title":"Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry","year":2019,"lang":"en","type":"article","venue":"iScience","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Science and Engineering Research Board; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Indo-US Science and Technology Forum; W. M. Keck Foundation","keywords":"Lysosome; Exocytosis; Cell biology; Secretion; Biology; Plasmodium (life cycle); Lipid bilayer fusion; LAMP1; Rab; Endosome; Parasite hosting; GTPase; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130899,0.0001074621,0.0001764131,0.00006014893,0.00007301407,0.00005838021,0.00009706542,0.00005055421,0.0001475768],"category_scores_gemma":[0.00004674451,0.00008349423,0.0000459685,0.0001734589,0.00009297195,0.0002042339,0.00004961306,0.00008330067,0.0001102231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000247552,"about_ca_system_score_gemma":0.00008604829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003559569,"about_ca_topic_score_gemma":0.000003157591,"domain_scores_codex":[0.9989685,0.00001949572,0.0001295425,0.0003514474,0.0002903805,0.0002406394],"domain_scores_gemma":[0.9994572,0.00003343807,0.00005624631,0.0002348518,0.0000446836,0.0001735889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002926723,0.0001764987,0.6524913,0.0001760278,0.00003026439,0.00003791914,0.0006820008,0.000007808033,0.3204845,0.0009924225,0.0002053412,0.02442334],"study_design_scores_gemma":[0.002372143,0.0007245639,0.9470727,0.0002737951,0.0001212991,0.00008922941,0.0003231865,0.01528932,0.02990483,0.0003228627,0.003180411,0.0003256501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957542,0.001096069,0.00006206891,0.0007966004,0.0001447781,0.0004174558,0.000007555785,0.00004378025,0.001677431],"genre_scores_gemma":[0.9985135,0.0000821389,0.00007894322,0.0004716998,0.00007079981,0.00002357392,0.000005849286,0.000007128483,0.000746349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2945815,"threshold_uncertainty_score":0.3404796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187038457679384,"score_gpt":0.2564591789700221,"score_spread":0.2445887943932283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}