{"id":"W2982325216","doi":"10.1016/j.isci.2019.10.054","title":"Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry","year":2019,"lang":"en","type":"article","venue":"iScience","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Science and Engineering Research Board; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Indo-US Science and Technology Forum; W. M. Keck Foundation","keywords":"Lysosome; Exocytosis; Cell biology; Secretion; Biology; Plasmodium (life cycle); Lipid bilayer fusion; LAMP1; Rab; Endosome; Parasite hosting; GTPase; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009359816,0.0001602088,0.0001678775,0.0001252398,0.0001112208,0.0002546415,0.0000615552,0.0001291922,0.0012737],"category_scores_gemma":[0.00009607364,0.0001099541,0.0001377765,0.00009253754,0.0001181678,0.0001379145,0.0002433133,0.0003132806,0.0004119295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389667,"about_ca_system_score_gemma":0.000160674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002682306,"about_ca_topic_score_gemma":0.0004974422,"domain_scores_codex":[0.9999245,0.00001748361,0.000006292275,0.000009701794,0.00001962953,0.00002224877],"domain_scores_gemma":[0.9999346,0.00001163764,0.00001466335,0.000007208836,0.000009251546,0.0000226496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001865559,0.00002542742,0.0003305072,0.00004142815,0.000002994624,0.00009578699,0.00001943036,0.00002878605,0.9978271,0.0001242336,0.00008344108,0.0012344],"study_design_scores_gemma":[0.00004098814,0.0003854747,0.01784142,0.000009083991,0.00001272562,0.0003788465,0.00007342804,0.001362906,0.9765365,0.00008560139,0.003267935,0.000005035383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951035,0.0006813803,0.001534869,0.000130472,0.00002253449,0.0000204294,0.0001943022,0.00008305738,0.002229398],"genre_scores_gemma":[0.9961993,0.0004341824,0.0008627949,0.00003766195,0.000009235157,0.00001178679,0.000268223,0.0000177089,0.002159015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0012737,"threshold_uncertainty_score":0.004260898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187038457679384,"score_gpt":0.2564591789700221,"score_spread":0.2445887943932283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}