{"id":"W2982328392","doi":"10.1101/824946","title":"SLAMF6 deficiency augments tumor killing and skews towards an effector phenotype revealing it as a novel T cell checkpoint","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Azrieli Foundation; Israel Science Foundation; Deutsche Forschungsgemeinschaft; International Development Research Centre; American Academy of Allergy, Asthma and Immunology Foundation; Rosetrees Trust; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Canadian Institutes of Health Research; Melanoma Research Alliance","keywords":"Cytotoxic T cell; Biology; CD8; Effector; Adoptive cell transfer; Cytolysis; Immunology; Immune system; Cell biology; Phenotype; Interleukin 21; Transgene; Cancer research; T cell; In vitro; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009213313,0.0002674453,0.000137419,0.0001696159,0.00008422053,0.0001869213,0.0001114534,0.0003287648,0.00181329],"category_scores_gemma":[0.00006014352,0.0000669256,0.0001404749,0.0000657932,0.0001509042,0.000154293,0.0001409007,0.0005418804,0.0004672748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001350233,"about_ca_system_score_gemma":0.00006312961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001053706,"about_ca_topic_score_gemma":0.0001263017,"domain_scores_codex":[0.9999269,0.00001032461,0.000007103303,0.00001321563,0.00001693604,0.00002546988],"domain_scores_gemma":[0.9999462,0.000008258608,0.00001150198,0.00000723194,0.000005577017,0.00002128338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005962779,0.000007323184,0.00008012784,0.00000926245,6.685278e-7,0.00004031098,0.000002562279,0.0000176903,0.9993361,0.00005193116,0.00001851483,0.0003756946],"study_design_scores_gemma":[0.00001288043,0.0001480663,0.002468212,0.000003720924,0.000004137873,0.0004578751,0.000008968193,0.0004422286,0.994868,0.00006664077,0.001517528,0.000001603457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950885,0.0006139018,0.002506988,0.00009547883,0.00002056872,0.00001254699,0.0002942217,0.0001101121,0.001257742],"genre_scores_gemma":[0.9951051,0.0001915525,0.001181082,0.0000319773,0.00001248114,0.00001033895,0.0003105852,0.00001896737,0.003137839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00181329,"threshold_uncertainty_score":0.006066084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400280758998237,"score_gpt":0.2275532762024207,"score_spread":0.2135504686124383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}