{"id":"W2982361973","doi":"10.1158/1078-0432.ccr-19-1611","title":"MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Key Research and Development Program of China; Health and Medical Research Fund","keywords":"Chromosome instability; Colorectal cancer; Cancer research; Carcinogenesis; Cancer; Knockout mouse; Microsatellite instability; Genome instability; Mouse model of colorectal and intestinal cancer; Biology; Azoxymethane; Aneuploidy; Chromosome; Genetics; DNA damage; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001065216,0.0001895355,0.000220889,0.0004164239,0.0001903995,0.0001729262,0.0001146657,0.0002039636,0.001824798],"category_scores_gemma":[0.0003299712,0.00009850247,0.0001422294,0.0003126525,0.0001149481,0.0001278642,0.0001920207,0.0002405784,0.0002554116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366268,"about_ca_system_score_gemma":0.00008999511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003423489,"about_ca_topic_score_gemma":0.0004730848,"domain_scores_codex":[0.9999005,0.00001504289,0.000008826812,0.00003247619,0.00002418543,0.00001901933],"domain_scores_gemma":[0.9996992,0.00003316094,0.000148305,0.00002016268,0.00002786435,0.00007138213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001725485,0.00007837929,0.8999972,0.0000788238,0.0001087497,0.001287403,0.00004567788,0.00009359612,0.08725086,0.0000485649,0.0003395617,0.008945748],"study_design_scores_gemma":[0.000007684001,0.0002329488,0.9900051,0.000004618786,0.00004452244,0.002598385,0.00003823786,0.0001770841,0.0061362,0.00002048262,0.0007316122,0.000003202648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998727,0.0004924624,0.0002243628,0.00002327254,0.00000414281,0.000004253793,0.0002811841,0.00001559489,0.0002275802],"genre_scores_gemma":[0.9991624,0.0001585264,0.0001028113,0.00001152596,0.000004768736,0.00000396796,0.0003106943,0.000002706538,0.000242468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824798,"threshold_uncertainty_score":0.006104529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03641800314611702,"score_gpt":0.3696162983407031,"score_spread":0.333198295194586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}