{"id":"W2982361973","doi":"10.1158/1078-0432.ccr-19-1611","title":"MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Key Research and Development Program of China; Health and Medical Research Fund","keywords":"Chromosome instability; Colorectal cancer; Cancer research; Carcinogenesis; Cancer; Knockout mouse; Microsatellite instability; Genome instability; Mouse model of colorectal and intestinal cancer; Biology; Azoxymethane; Aneuploidy; Chromosome; Genetics; DNA damage; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009479058,0.0002081988,0.0004818903,0.00006039763,0.00009629191,0.0000295603,0.0002759279,0.0002858508,0.0001858205],"category_scores_gemma":[0.0002379311,0.0001565286,0.00008903362,0.0003041672,0.0008715749,0.00001197775,0.0002543513,0.0003922309,0.000003972226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009066291,"about_ca_system_score_gemma":0.0008870494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004872651,"about_ca_topic_score_gemma":0.002603313,"domain_scores_codex":[0.9974332,0.0003923893,0.0004423205,0.0006788061,0.000540602,0.0005126116],"domain_scores_gemma":[0.9982417,0.0002678834,0.0001754117,0.000257979,0.0008679618,0.0001890446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004069461,0.0004468323,0.9769558,0.00007563676,0.0003021805,0.000004119591,0.00005665404,0.000007220411,0.01715435,0.000008154101,0.0002282048,0.0006914152],"study_design_scores_gemma":[0.00519751,0.004859869,0.9134043,0.0001304401,0.00005264134,0.000001279184,0.00009723938,0.0000559714,0.0749075,0.00001341389,0.0009565076,0.0003233204],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975452,0.0005053707,0.000002448159,0.0001182379,0.0001693223,0.000792234,0.0006658332,0.000008534433,0.000192831],"genre_scores_gemma":[0.998203,0.001074955,0.00002128525,0.00009370213,0.000116426,0.0001135407,0.0001902508,0.00004203193,0.0001448093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06355146,"threshold_uncertainty_score":0.6383052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03641800314611702,"score_gpt":0.3696162983407031,"score_spread":0.333198295194586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}