{"id":"W2982377894","doi":"10.1186/s13059-019-1833-x","title":"Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues","year":2019,"lang":"en","type":"article","venue":"Genome biology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"European Research Council; Medical Research Council; Fondazione Pierfranco e Luisa Mariani; Bundesministerium für Bildung und Forschung; E-Rare; Agence Nationale de la Recherche; Biotechnology and Biological Sciences Research Council; Ministero della Salute","keywords":"Biology; Endogenous retrovirus; Imprinting (psychology); Embryonic stem cell; Genomic imprinting; Genetics; Computational biology; Human genetics; Endogeny; Evolutionary biology; Cell biology; Genome; Gene; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003093209,0.0006719672,0.0001904712,0.0004009832,0.0002057287,0.0004795774,0.0009109157,0.0005448732,0.004794605],"category_scores_gemma":[0.0001834593,0.000411299,0.0003715701,0.0002760773,0.000427502,0.0002614375,0.0005709939,0.001423427,0.001487476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005291685,"about_ca_system_score_gemma":0.000304476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004005746,"about_ca_topic_score_gemma":0.001119125,"domain_scores_codex":[0.9995368,0.0000412644,0.00005160382,0.0001137864,0.0001575793,0.00009911189],"domain_scores_gemma":[0.9996101,0.00008402626,0.0001301306,0.00006830166,0.00002294315,0.00008444253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004165874,0.00003017981,0.0001856761,0.00003644291,0.000004824254,0.00006839397,0.00002104097,0.00002928653,0.9982956,0.0003625473,0.00003987893,0.0008844648],"study_design_scores_gemma":[0.00006248512,0.0002843308,0.005223556,0.00002111528,0.00004065099,0.0006614415,0.00004378364,0.001056449,0.9824563,0.0001492877,0.009993219,0.000007344736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967541,0.002165142,0.0192926,0.0001937003,0.0001811038,0.0002945307,0.002332247,0.0008420145,0.007157663],"genre_scores_gemma":[0.955575,0.001147804,0.01454567,0.0001532786,0.00004133405,0.0001893665,0.005516455,0.000294686,0.02253642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004794605,"threshold_uncertainty_score":0.01603955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450027822078375,"score_gpt":0.245140502054765,"score_spread":0.2306402238339813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}