{"id":"W2982384088","doi":"10.3389/fimmu.2019.02473","title":"Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Canadian Institutes of Health Research; Österreichischen Akademie der Wissenschaften","keywords":"Downregulation and upregulation; Immune system; Cell biology; Biology; Receptor; Immunological synapse; Lymphocyte; Immunology; T lymphocyte; Mutation; T-cell receptor; T cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001184761,0.000688281,0.0003438609,0.0005607139,0.0002592082,0.000329346,0.0003876932,0.000906023,0.002553799],"category_scores_gemma":[0.0002953823,0.000160559,0.0005167791,0.0002396887,0.0005415812,0.0002063211,0.0004216006,0.0008145995,0.0007080899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002927668,"about_ca_system_score_gemma":0.0002095148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003180432,"about_ca_topic_score_gemma":0.0003239741,"domain_scores_codex":[0.9997929,0.00004069498,0.00003251986,0.00004741468,0.00004095088,0.00004552101],"domain_scores_gemma":[0.9997215,0.00007250799,0.0001010256,0.00002815842,0.00001697253,0.00005984554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002660664,0.0000544377,0.0003552634,0.00003509376,0.00001504954,0.001909243,0.00003243823,0.0001062413,0.9952375,0.0002488951,0.0001367907,0.001602883],"study_design_scores_gemma":[0.000137398,0.0008008478,0.006173945,0.00002920804,0.00009527165,0.01465566,0.0001223037,0.00201301,0.9701075,0.0004605633,0.0053719,0.00003227069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918913,0.0006131099,0.004426011,0.0002414995,0.0001283967,0.00004340038,0.000493927,0.0004070773,0.001755286],"genre_scores_gemma":[0.9939733,0.000537752,0.00215196,0.0001243379,0.00003097564,0.00004925594,0.0003533855,0.0001047073,0.002674392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002553799,"threshold_uncertainty_score":0.008543253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01865483413583861,"score_gpt":0.2525617473158555,"score_spread":0.2339069131800169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}