{"id":"W2982411421","doi":"10.1158/1541-7786.mcr-19-0582","title":"Antibody–Drug Conjugates: A Comprehensive Review","year":2019,"lang":"en","type":"review","venue":"Molecular Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":770,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Antibody-drug conjugate; Drug; Payload (computing); Monoclonal antibody; Cytotoxic T cell; Immunotherapy; Computational biology; Cancer immunotherapy; Cancer research; Medicine; Pharmacology; Cancer; Antibody; Chemistry; Biology; Computer science; Immunology; In vitro; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000449406,0.0009840383,0.001089662,0.002357547,0.0002492551,0.0008873161,0.0006919525,0.0008566852,0.007332601],"category_scores_gemma":[0.0005731789,0.0003196174,0.0005239042,0.002352698,0.000249372,0.001155252,0.0005728389,0.001345271,0.003735789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004925667,"about_ca_system_score_gemma":0.001029406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007810925,"about_ca_topic_score_gemma":0.00151575,"domain_scores_codex":[0.9998254,0.0000269806,0.00002445564,0.00003072079,0.00007384211,0.00001860313],"domain_scores_gemma":[0.9997914,0.00009473979,0.00003212011,0.000007609097,0.00005580396,0.00001837836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005759953,0.0001126576,0.0001040422,0.02235985,0.00007522252,0.0001555167,0.00004800753,0.0004270131,0.002501348,0.003717695,0.04352245,0.9269187],"study_design_scores_gemma":[0.000009473484,0.00006661639,0.0001985735,0.002005375,0.00005495084,0.0004726702,0.00001592671,0.00005551895,0.0004044742,0.0006198236,0.9960872,0.000009440728],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001888754,0.9968437,0.000195935,0.0001926981,0.0002850868,0.00001250586,0.00004675806,0.00001511657,0.002219347],"genre_scores_gemma":[0.0006997648,0.9974602,0.000300277,0.0001723945,0.0001347413,0.00001283032,0.00006675817,0.000002467212,0.001150448],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007332601,"threshold_uncertainty_score":0.02452999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.354517806902707,"score_gpt":0.6034749384917816,"score_spread":0.2489571315890746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}