{"id":"W2982435333","doi":"10.3390/cells8111341","title":"MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)—Current Treatment Options. Is There a Role for CAR-T Cell Therapy?","year":2019,"lang":"en","type":"review","venue":"Cells","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"AXYS Technologies (Canada)","funders":"","keywords":"Leukemia; Chromosomal translocation; Myeloid leukemia; Acute leukemia; Medicine; Oncology; Cancer research; Fusion gene; Internal medicine; Immunology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003327664,0.001187727,0.003260607,0.0003850788,0.0001615052,0.0001221761,0.0005215985,0.0005907729,0.003603315],"category_scores_gemma":[0.000004941494,0.0007424639,0.001745755,0.0004941968,0.0001495856,0.00007145174,0.00007663879,0.0007390606,0.0009948851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002023147,"about_ca_system_score_gemma":0.002698321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001659408,"about_ca_topic_score_gemma":0.00002597982,"domain_scores_codex":[0.9959292,0.0002389319,0.0007447629,0.001269947,0.0007771144,0.001040014],"domain_scores_gemma":[0.9965789,0.0003669969,0.0004201533,0.001911737,0.0002812955,0.0004408587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005153422,0.0005688295,0.00001029705,0.01010092,0.001922189,0.00006284249,0.0005359671,0.000002002899,0.001641847,0.000007236191,0.007367737,0.9772648],"study_design_scores_gemma":[0.005532536,0.00237975,0.000003155551,0.004566479,0.00357111,0.00006352118,0.00007198181,0.00002502707,0.003431498,0.00000734735,0.9796445,0.0007031003],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005869296,0.9816056,0.00003248701,0.00008132584,0.0004830455,0.0110565,0.0007408297,0.0001161514,0.005297125],"genre_scores_gemma":[0.00002213268,0.8866967,0.0002854137,0.0000817266,0.0007001197,0.001850015,0.0007913332,0.000368002,0.1092045],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9765617,"threshold_uncertainty_score":0.999783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08670962398240774,"score_gpt":0.3794430066666013,"score_spread":0.2927333826841936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}