{"id":"W2982443853","doi":"10.1101/825166","title":"CRISPR/Cas9 mediated intersectional knockout of GSK3β in D2 receptor expressing mPFC neurons reveals contributions to emotional regulation","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Prefrontal cortex; Neuroscience; GSK-3; Dopamine receptor D2; Synaptic plasticity; Biology; Dopamine; Psychology; Cognition; Receptor; Signal transduction; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001530042,0.0004854373,0.0003684231,0.0003162029,0.0002339995,0.000452508,0.000428504,0.0005319329,0.001958085],"category_scores_gemma":[0.0001430131,0.0002204888,0.0005144858,0.0001904645,0.0003896254,0.0001719941,0.0004146045,0.0009306521,0.0005766063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004662337,"about_ca_system_score_gemma":0.0003873924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00178561,"about_ca_topic_score_gemma":0.002711516,"domain_scores_codex":[0.9997366,0.00001310309,0.00003122041,0.00008606791,0.00008369473,0.00004930634],"domain_scores_gemma":[0.9998629,0.00001937546,0.00004643364,0.00002180067,0.00001241182,0.00003704714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008950651,0.00001580793,0.0003305712,0.0000577774,0.00001451057,0.0001944216,0.0000297241,0.0002189022,0.9972032,0.0002992809,0.0001246906,0.001421523],"study_design_scores_gemma":[0.00002889916,0.00009032282,0.004808884,0.00001575869,0.00005031952,0.0005982117,0.00005905376,0.003171443,0.9846901,0.000154123,0.006316492,0.00001641014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9397509,0.00133314,0.04720067,0.0003103664,0.0001598792,0.0001289491,0.004366598,0.001198987,0.005550624],"genre_scores_gemma":[0.979144,0.0006165705,0.01380278,0.0001475929,0.000009033824,0.0001188437,0.001428498,0.0001271013,0.004605502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001958085,"threshold_uncertainty_score":0.006550431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008519536261669918,"score_gpt":0.2652714662428015,"score_spread":0.2567519299811316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}