{"id":"W2982464227","doi":"10.1158/2159-8290.cd-18-1463","title":"Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene–Driven Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Gertrude von Meissner-Stiftung; Institut Gustave-Roussy; Cancéropôle Ile de France; Fondation de France; Fondation pour la Recherche Médicale; Blood Cancer UK; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Novartis Foundation; Association Laurette Fugain; Health Research Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Direction Générale de l’offre de Soins; National Science Foundation","keywords":"Biology; Myeloid leukemia; Phenotype; Cancer research; Myeloid; Haematopoiesis; Oncogene; Fusion gene; Oncogene Proteins; Leukemia; Transcriptome; GATA1; Stem cell; Immunology; Genetics; Cell cycle; Regulation of gene expression; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002300264,0.0002933447,0.0005538919,0.0005124127,0.00004234342,0.00004881996,0.0002061331,0.0001393395,0.0003464234],"category_scores_gemma":[0.0001100932,0.0002621928,0.00008283263,0.0006865329,0.0001014033,0.0002940773,0.0002862703,0.0005178757,0.00006934672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002371276,"about_ca_system_score_gemma":0.001852783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008182324,"about_ca_topic_score_gemma":0.002055005,"domain_scores_codex":[0.9977523,0.00008847423,0.000353604,0.0007065981,0.0004679601,0.0006310524],"domain_scores_gemma":[0.9987693,0.0001326572,0.00009437376,0.0005394215,0.00005147144,0.0004127796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001365403,0.0001214499,0.9724696,0.0008725291,0.00002114365,0.0003720736,0.0005750643,0.0001406744,0.01878144,0.00007020426,0.0003825598,0.004827891],"study_design_scores_gemma":[0.00627169,0.0002609693,0.9861811,0.0005075199,0.0001060596,0.00002212617,0.0002717988,0.002178441,0.002258499,0.0003168724,0.001125782,0.0004991852],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899805,0.006805625,0.00001390651,0.001290624,0.0002340924,0.001080442,0.0000597668,0.00003078717,0.0005042475],"genre_scores_gemma":[0.987774,0.008436446,0.0000739735,0.0005412915,0.0005424053,0.0001415299,0.00004552161,0.00005758051,0.002387303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01652294,"threshold_uncertainty_score":0.999983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914141462022989,"score_gpt":0.2808454084909132,"score_spread":0.2617039938706833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}