{"id":"W2982464227","doi":"10.1158/2159-8290.cd-18-1463","title":"Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene–Driven Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Gertrude von Meissner-Stiftung; Institut Gustave-Roussy; Cancéropôle Ile de France; Fondation de France; Fondation pour la Recherche Médicale; Blood Cancer UK; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Novartis Foundation; Association Laurette Fugain; Health Research Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Direction Générale de l’offre de Soins; National Science Foundation","keywords":"Biology; Myeloid leukemia; Phenotype; Cancer research; Myeloid; Haematopoiesis; Oncogene; Fusion gene; Oncogene Proteins; Leukemia; Transcriptome; GATA1; Stem cell; Immunology; Genetics; Cell cycle; Regulation of gene expression; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001748385,0.0001304582,0.0001388749,0.0001929775,0.0000987212,0.000314494,0.0001356172,0.0002652134,0.0007886604],"category_scores_gemma":[0.0001087156,0.00008243031,0.0001048037,0.0001353427,0.0003119459,0.000155185,0.0002895504,0.0006027182,0.0002678858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004175953,"about_ca_system_score_gemma":0.0001903997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000397583,"about_ca_topic_score_gemma":0.001010385,"domain_scores_codex":[0.9998959,0.00001819005,0.000005996245,0.00002711364,0.00003335754,0.0000194767],"domain_scores_gemma":[0.9999207,0.00002064179,0.00002508793,0.000005567144,0.00001427497,0.0000137724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002152049,0.00001213016,0.002769787,0.00005005657,0.000005113498,0.0003682806,0.00007753105,0.0001215099,0.9852051,0.00103293,0.0006655621,0.009476882],"study_design_scores_gemma":[0.00003158814,0.0004758774,0.1307004,0.00006163543,0.00005122148,0.005205479,0.0004354111,0.001360946,0.7854056,0.001357838,0.07488287,0.00003118834],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628026,0.01578289,0.01004165,0.002369994,0.0002629708,0.00005091056,0.001015272,0.000265763,0.00740786],"genre_scores_gemma":[0.9767601,0.01352045,0.001925316,0.0005694373,0.0001380078,0.00003364613,0.000623638,0.00009008328,0.006339444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007886604,"threshold_uncertainty_score":0.003029823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914141462022989,"score_gpt":0.2808454084909132,"score_spread":0.2617039938706833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}