{"id":"W2982472170","doi":"10.3390/genes10110870","title":"Helicases FANCJ, RTEL1 and BLM Act on Guanine Quadruplex DNA in Vivo","year":2019,"lang":"en","type":"review","venue":"Genes","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Helicase; Telomere; Biology; Genome instability; Context (archaeology); Genome; DNA; Gene; Genetics; G-quadruplex; Cell biology; DNA damage; Computational biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000881259,0.0003998353,0.0007619095,0.0000569819,0.00003094565,0.00002837837,0.0002628126,0.0004871106,0.00008903092],"category_scores_gemma":[0.00003705972,0.000332815,0.0002142937,0.00008289685,0.00005739772,0.000001958236,0.0001826567,0.0001493816,0.00005102628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001833522,"about_ca_system_score_gemma":0.00009548435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000797253,"about_ca_topic_score_gemma":0.000009961294,"domain_scores_codex":[0.9986382,0.00003341389,0.00031741,0.0006182205,0.0001102066,0.0002825838],"domain_scores_gemma":[0.9992428,0.00002304632,0.0001436748,0.0004867524,0.00002304012,0.0000806895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003780566,0.00009968354,0.00008820025,0.007639374,0.0001612357,0.00002898633,0.00001122218,8.076703e-7,0.04935864,0.00001860714,0.007687156,0.9348683],"study_design_scores_gemma":[0.0001983792,0.0001172539,0.000008351203,0.001045423,0.00009956595,0.0000608932,0.00001067819,7.715308e-7,0.02845289,0.000002809876,0.9696332,0.0003697443],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03405972,0.9626166,0.000001043497,0.00001558724,0.0001435016,0.00024445,0.000109849,0.00001204642,0.002797191],"genre_scores_gemma":[0.0008646736,0.9948248,0.00004940576,0.00009633738,0.0004548085,0.00003896767,0.0002269879,0.0000597485,0.003384326],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9619461,"threshold_uncertainty_score":0.9999124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03301218235268946,"score_gpt":0.3152726227626693,"score_spread":0.2822604404099798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}