{"id":"W2982514984","doi":"10.1182/bloodadvances.2019000641","title":"Replication timing alterations in leukemia affect clinically relevant chromosome domains","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Replication timing; Lineage (genetic); Epigenetics; Leukemia; DNA replication; Cellular differentiation; DNA methylation; CD34; Genetics; DNA; Immunology; Gene; Stem cell; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009242422,0.0001397594,0.0001226015,0.000289957,0.00008487018,0.0001621695,0.00007043975,0.0001249807,0.00110687],"category_scores_gemma":[0.0003209794,0.00007598833,0.00007554983,0.0002183257,0.0001102949,0.0001164959,0.0001438125,0.0001427315,0.0001755002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170744,"about_ca_system_score_gemma":0.00008179872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004246113,"about_ca_topic_score_gemma":0.0008278492,"domain_scores_codex":[0.9999189,0.00001545803,0.000007357412,0.0000264046,0.00001836374,0.00001342703],"domain_scores_gemma":[0.9998786,0.00002413681,0.00006187786,0.00001672698,0.000007945484,0.00001062855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004100507,0.00002005146,0.03186397,0.00003500517,0.0000175681,0.0002417929,0.00005197522,0.000426161,0.9553438,0.0002545244,0.0000672401,0.01126777],"study_design_scores_gemma":[0.00003439502,0.0006081384,0.5966551,0.0000109147,0.00007089043,0.006919666,0.0001117426,0.001743347,0.388156,0.000459556,0.005216545,0.00001380582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997837,0.0004677501,0.0007803463,0.00001386007,0.000002090721,0.00000929496,0.0002243495,0.00003778375,0.0006274804],"genre_scores_gemma":[0.9989827,0.0001801521,0.0003583191,0.000009566083,0.000002126586,0.000006065468,0.0002016676,0.000006263656,0.0002530659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00110687,"threshold_uncertainty_score":0.003702819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02001451847410559,"score_gpt":0.34170447513679,"score_spread":0.3216899566626845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}