{"id":"W2982514984","doi":"10.1182/bloodadvances.2019000641","title":"Replication timing alterations in leukemia affect clinically relevant chromosome domains","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Replication timing; Lineage (genetic); Epigenetics; Leukemia; DNA replication; Cellular differentiation; DNA methylation; CD34; Genetics; DNA; Immunology; Gene; Stem cell; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005876094,0.0001595484,0.0003607606,0.0001593772,0.0000607681,0.00002690231,0.0001842732,0.0001138116,0.0001335163],"category_scores_gemma":[0.001045028,0.0001343677,0.00008450482,0.0003861045,0.00008085823,0.000288781,0.0000776063,0.000320893,0.0003870657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005055437,"about_ca_system_score_gemma":0.0006730419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003294049,"about_ca_topic_score_gemma":0.00003342469,"domain_scores_codex":[0.9979813,0.00008128431,0.0005289041,0.0006122641,0.0004192468,0.0003769682],"domain_scores_gemma":[0.9980489,0.0006657609,0.0001374056,0.0009129237,0.0000948347,0.0001401925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002021067,0.001683784,0.4780323,0.001315249,0.0003388503,0.0007319253,0.001501371,0.002189765,0.4506888,0.004695589,0.001739338,0.055062],"study_design_scores_gemma":[0.08499934,0.01252652,0.5069904,0.006511126,0.00101311,0.002626361,0.001579201,0.06620014,0.1840824,0.006010463,0.1245034,0.002957482],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988064,0.0006075758,0.000447808,0.000858078,0.0001475375,0.0009547472,0.000008655783,0.00009663909,0.008814985],"genre_scores_gemma":[0.9881594,0.0005173838,0.008308143,0.0004317034,0.0002502499,0.0001021874,0.00006220327,0.00003258653,0.002136159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2666064,"threshold_uncertainty_score":0.5479358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02001451847410559,"score_gpt":0.34170447513679,"score_spread":0.3216899566626845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}