{"id":"W2982554531","doi":"10.1038/s41573-019-0047-y","title":"Targeted protein degradation: expanding the toolbox","year":2019,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":938,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Wellcome Trust","keywords":"Drug discovery; Ubiquitin; Protein degradation; Computational biology; Proteasome; Toolbox; Proteolysis; Ubiquitin ligase; Chemical biology; Drug; Drug development; Bioinformatics; Computer science; Biology; Pharmacology; Cell biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02643913160446375,"score_gpt":0.3262636766066986,"score_spread":0.2998245450022348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}